Cancer progress and priorities: breast cancer

SC Houghton, SE Hankinson - Cancer epidemiology, biomarkers & …, 2021 - AACR
Breast cancer is the most commonly diagnosed invasive cancer among women both
globally and within the United States and the number one cause of cancer-related deaths …

Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics

A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

The lipogenic regulator SREBP2 induces transferrin in circulating melanoma cells and suppresses ferroptosis

X Hong, W Roh, RJ Sullivan, KHK Wong, BS Wittner… - Cancer discovery, 2021 - AACR
Circulating tumor cells (CTC) are shed by cancer into the bloodstream, where a viable
subset overcomes oxidative stress to initiate metastasis. We show that single CTCs from …

Prediction of sepsis patients using machine learning approach: a meta-analysis

MM Islam, T Nasrin, BA Walther, CC Wu… - Computer methods and …, 2019 - Elsevier
Study objective Sepsis is a common and major health crisis in hospitals globally. An
innovative and feasible tool for predicting sepsis remains elusive. However, early and …

A Mendelian randomization study of the effects of blood lipids on breast cancer risk

C Nowak, J Ärnlöv - Nature communications, 2018 - nature.com
Observational studies have reported inconsistent associations between circulating lipids
and breast cancer risk. Using results from> 400,000 participants in two-sample Mendelian …

[HTML][HTML] PCSK9 and cancer: Rethinking the link

K Mahboobnia, M Pirro, E Marini, F Grignani… - Biomedicine & …, 2021 - Elsevier
Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

HDL and LDL: potential new players in breast cancer development

L Cedó, ST Reddy, E Mato, F Blanco-Vaca… - Journal of clinical …, 2019 - mdpi.com
Breast cancer is the most prevalent cancer and primary cause of cancer-related mortality in
women. The identification of risk factors can improve prevention of cancer, and obesity and …

Updating the role of obesity and cholesterol in breast cancer

L Garcia-Estevez, G Moreno-Bueno - Breast Cancer Research, 2019 - Springer
Background Breast cancer is the second most common cause of cancer-related death
among women. Advances in our understanding of the disease have translated into better …

[HTML][HTML] Statins in risk-reduction and treatment of cancer

CI Barbalata, LR Tefas, M Achim, I Tomuta… - World journal of …, 2020 - ncbi.nlm.nih.gov
Statins, which are competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A
reductase, reduce cholesterol blood levels and the risk of developing cardiovascular …

Targeting the mevalonate pathway in cancer

D Juarez, DA Fruman - Trends in cancer, 2021 - cell.com
The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …