Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Sphingolipid metabolism in metazoan cells consists of a complex interconnected web of
numerous enzymes, metabolites and modes of regulation. At the centre of sphingolipid …

Recent technological innovations have ignited an explosion in virus genome sequencing
that promises to fundamentally alter our understanding of viral biology and profoundly …

Background Accurate estimation of the isoelectric point (pI) based on the amino acid
sequence is useful for many analytical biochemistry and proteomics techniques such as 2-D …

Among other effects, post-translational modifications (PTMs) have been shown to exert their
function via the modulation of protein-protein interactions. For twelve different main PTM …

Pfam is a widely used database of protein families, currently containing more than 13 000
manually curated protein families as of release 26.0. Pfam is available via servers in the UK …

HMMER is a software suite for protein sequence similarity searches using probabilistic
methods. Previously, HMMER has mainly been available only as a computationally …

Abstract The UCSC Genome Browser (http://genome. ucsc. edu) is a graphical viewer for
genomic data now in its 13th year. Since the early days of the Human Genome Project, it has …

Abstract The National Center for Biotechnology Information (NCBI) Reference Sequence
(RefSeq) database is a collection of genomic, transcript and protein sequence records …

Abstract DrugBank (http://www. drugbank. ca) is a richly annotated database of drug and
drug target information. It contains extensive data on the nomenclature, ontology, chemistry …