To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Numerous studies have reported significant associations between ABO blood group and risk
of cardiovascular disease. These studies have consistently demonstrated that thrombotic …

Atrial disease or myopathy forms the substrate for atrial fibrillation (AF) and underlies the
potential for atrial thrombus formation and subsequent stroke. Current diagnostic …

Background Consistent with fulminant endothelial cell activation, elevated plasma von
Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19. The …

Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a
century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver …

Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates
platelet adhesion along the endothelium. In addition to its role maintaining normal …

ABO blood group antigens are complex carbohydrate molecules expressed on red blood
cells and a variety of tissues. The ABO blood type is implicated in the development of a …

Essentials• von Willebrand factor (VWF) and factor VIII (FVIII) levels are modulated by age
and ABO status.• The effect of aging and ABO blood type on VWF and FVIII was assessed in …

Tumor cell shave the ability to induce platelet activation and aggregation. This has been
documented to be involved in tumor progression in several types of cancers, such as lung …

Von Willebrand disease (VWD) constitutes the most common inherited human bleeding
disorder. It is associated with a mucocutaneous bleeding phenotype that can significantly …