The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

The programmed cell death (PCD) of developing cells is considered an essential adaptive
process that evolved to serve diverse roles. We review the putative adaptive functions of …

In Parkinson's disease, brain dopamine neurons degenerate most prominently in the
substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of …

Neuronal morphological differentiation is regulated by numerous polypeptide growth factors
(neurotrophic factors). Recently, significant progress has been achieved in clarifying the …

Many distinct regulatory factors have been shown to be required for the proper initiation of
neuron-type-specific differentiation programs, but much less is known about the regulatory …

Both blood vessels and nerves are guided to their tissue targets by “specific” growth factors
such as vascular endothelial growth factor (VEGF) and nerve growth factor (NGF), originally …

Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been
found. Neurotrophins are the main vertebrate secreted signalling molecules that link …

Binding of nerve growth factor (NGF) to the p75 neurotrophin receptor (p75) in cultured
hippocampal neurons has been reported to cause seemingly contrasting effects, namely …

MAPK/Erk is a protein kinase activated by neurotrophic factors involved in synapse
formation and plasticity, which acts at both the nuclear and cytoplasmic level. Synapsin …

Neurotrophins were originally identified as target-derived factors that regulate the survival
and differentiation of innervating neurons. However, neurotrophins can also be released by …