Neurotrophin signaling through the p75 neurotrophin receptor
The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …
maintenance, survival, and death of the nervous system. The signal transducing systems …
Adaptive roles of programmed cell death during nervous system development
RR Buss, W Sun, RW Oppenheim - Annu. Rev. Neurosci., 2006 - annualreviews.org
The programmed cell death (PCD) of developing cells is considered an essential adaptive
process that evolved to serve diverse roles. We review the putative adaptive functions of …
process that evolved to serve diverse roles. We review the putative adaptive functions of …
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
P Lindholm, MH Voutilainen, J Laurén, J Peränen… - Nature, 2007 - nature.com
In Parkinson's disease, brain dopamine neurons degenerate most prominently in the
substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of …
substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of …
Neurotrophic factors and axonal growth
A Markus, TD Patel, WD Snider - Current opinion in neurobiology, 2002 - Elsevier
Neuronal morphological differentiation is regulated by numerous polypeptide growth factors
(neurotrophic factors). Recently, significant progress has been achieved in clarifying the …
(neurotrophic factors). Recently, significant progress has been achieved in clarifying the …
BRN3-type POU homeobox genes maintain the identity of mature postmitotic neurons in nematodes and mice
Many distinct regulatory factors have been shown to be required for the proper initiation of
neuron-type-specific differentiation programs, but much less is known about the regulatory …
neuron-type-specific differentiation programs, but much less is known about the regulatory …
Cross talk between the cardiovascular and nervous systems: neurotrophic effects of vascular endothelial growth factor (VEGF) and angiogenic effects of nerve growth …
P Lazarovici, C Marcinkiewicz… - Current pharmaceutical …, 2006 - ingentaconnect.com
Both blood vessels and nerves are guided to their tissue targets by “specific” growth factors
such as vascular endothelial growth factor (VEGF) and nerve growth factor (NGF), originally …
such as vascular endothelial growth factor (VEGF) and nerve growth factor (NGF), originally …
Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation
B Zhu, JA Pennack, P McQuilton, MG Forero… - PLoS …, 2008 - journals.plos.org
Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been
found. Neurotrophins are the main vertebrate secreted signalling molecules that link …
found. Neurotrophins are the main vertebrate secreted signalling molecules that link …
Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral …
AB Brann, M Tcherpakov, IM Williams… - Journal of Biological …, 2002 - ASBMB
Binding of nerve growth factor (NGF) to the p75 neurotrophin receptor (p75) in cultured
hippocampal neurons has been reported to cause seemingly contrasting effects, namely …
hippocampal neurons has been reported to cause seemingly contrasting effects, namely …
MAPK/Erk-dependent phosphorylation of synapsin mediates formation of functional synapses and short-term homosynaptic plasticity
CNG Giachello, F Fiumara, C Giacomini… - Journal of cell …, 2010 - journals.biologists.com
MAPK/Erk is a protein kinase activated by neurotrophic factors involved in synapse
formation and plasticity, which acts at both the nuclear and cytoplasmic level. Synapsin …
formation and plasticity, which acts at both the nuclear and cytoplasmic level. Synapsin …
Location, location, location: a spatial view of neurotrophin signal transduction
HM Heerssen, RA Segal - Trends in neurosciences, 2002 - cell.com
Neurotrophins were originally identified as target-derived factors that regulate the survival
and differentiation of innervating neurons. However, neurotrophins can also be released by …
and differentiation of innervating neurons. However, neurotrophins can also be released by …