Background This is the third updated version of a Cochrane review first published in Issue 4,
2003 of The Cochrane Library and first updated in 2007. Morphine has been used for many …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Despite tremendous progress in medicine during last couple of decades, cancer still
remains the most horrifying diagnosis for anybody due to its almost inevitable futility …

Background: Pain is one of the most common symptoms in cancer patients. The Japanese
Society for Palliative Medicine (JSPM) first published its clinical guidelines for the …

Management of chronic noncancer pain (CNCP) requires a comprehensive assessment of
the patient, the institution of a structured treatment regimen, an ongoing reassessment of the …

Background There is increasing focus on providing high quality care for people at the end of
life, irrespective of disease or cause, and in all settings. In the last ten years the use of care …

Background: Buprenorphine is a mixed-activity, partial μ-opioid agonist. Its lipid solubility
makes it well suited for transdermal administration. Objective: This study assessed the …

Aims To compare the efficacy of slow‐release oral morphine (SROM) and methadone as
maintenance medication for opioid dependence in patients previously treated with …

Abstract Purpose of Review This article aims to provide an overview of standard and
adjunctive treatment options in opioid dependence in consideration of therapy-refractory …

Introduction: Effective pain management requires appropriate patient assessment, ongoing
reassessment, and an understanding of the options available for the treatment of patients …