Regulated necrosis (necroptosis) plays a pivotal role in the extent of cardiomyocyte loss and
the development of post-ischemic adverse remodelling and cardiac dysfunction following …

New Findings What is the central question of this study? What are the cardioprotective
effects of different aerobic exercises on chronic heart failure with different aetiologies, and is …

Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty
acids) oxidation based on nutrient availability. Pyruvate Dehydrogenase Kinase 4 (PDK4) is …

Mitochondria as dynamic organelles go through coordinated processes, including fusion
and apoptosis. This study was designed to assess the effects of L-carnitine supplement and …

Obesity and hypertension are common risk factors for cardiovascular disease whereas an
active lifestyle is considered as protective. However, the interaction between high physical …

Doxorubicin (DOX) is an anthracycline antibiotic that exhibits high heart toxicity. Human-
induced pluripotent stem cell-derived ventricular cardiomyocytes (hiPSC-vCMs) are …

Background: Prescription of sports activity is an effective strategy for treating metabolic
disorders, including obesity. The study aimed to determine the effect of 8 weeks of high …

Background: Inflammation is characterized by interactions between cytokines and
inflammatory pathogens. Cytokines are glycoproteins involved in inflammation. Exercise …

Purpose The real mechanisms of intensive exercise training-induced energy efficiency have
not yet been well examined. Therefore, the aim of the present study was to investigate the …

Background: Several lines of evidence revealed that chronic treatment of anabolic
androgenic steroids (AASs) is accompanied with some cardiovascular side effects and in …