As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …

The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

Multiple myeloma (MM) is a cancer of plasma cells that has been extensively studied in
recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …

More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the
discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has …

Germline loss-of-function mutations in the transcription factor signal transducer and activator
of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function …