Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review

NT Fakudze, P Sarbadhikary, BP George… - Pharmaceuticals, 2023 - mdpi.com
Africa is home to diverse medicinal plants that have been used for generations for the
treatment of several different cancers and, presently, they are gaining interest from …

Protective role of hesperetin in sorafenib-induced hepato-and neurotoxicity in mice via modulating apoptotic pathways and mitochondrial reprogramming

D Zaafar, HMA Khalil, R Elnaggar, DZ Saad… - Life Sciences, 2024 - Elsevier
Introduction Sorafenib, an FDA-approved standard chemotherapy for advanced
hepatocellular carcinoma, is associated with numerous adverse effects that significantly …

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

S Serini, G Calviello - Antioxidants, 2024 - mdpi.com
Chemotherapy-induced cognitive impairment or “chemobrain” is a prevalent long-term
complication of chemotherapy and one of the more devastating. Most of the studies …

Preparation and characterization of Sorafenib nano-emulsion: impact on pharmacokinetics and toxicity; an in vitro and in vivo study

D Zaafar, HMA Khalil, GE Elkhouly, AS Sedeky… - Drug Delivery and …, 2024 - Springer
Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related deaths
worldwide. Current treatment strategies include surgical resection, liver transplantation, liver …

Human Lung Cancer (A549) Cell Line Cytotoxicity and Anti-Leishmania major Activity of Carissa macrocarpa Leaves: A Study Supported by UPLC-ESI-MS/MS …

MAA Orabi, OS Alqahtani, BA Alyami, AA Al Awadh… - Pharmaceuticals, 2022 - mdpi.com
Lung cancer and cutaneous leishmaniasis are critical diseases with a relatively higher
incidence in developing countries. In this research, the activity of Carissa macrocarpa leaf …

Hyperoside alleviates doxorubicin-induced myocardial cells apoptosis by inhibiting the apoptosis signal-regulating kinase 1/p38 pathway

L Chen, Z Qin, Z Ruan - PeerJ, 2023 - peerj.com
Background Cardiotoxicity is a side effect of the anthracycline broad-spectrum anti-tumor
agent, doxorubicin (DOX). Hyperoside, a flavonoid glycoside extracted from many herbs …

[PDF][PDF] The role of pioglitazone against ehrlich solid carcinoma mice model through antiproliferative and antiangiogenic pathways

D Zaafar, HMA Khalil, S Hassanin, MR Mousa… - Adv. Anim. Vet …, 2023 - academia.edu
Background: Cancer is one of the leading causes of death and morbidity worldwide, and it is
linked to a variety of genetic and hormonal factors. Patients frequently experience cancer …

Effect of Carissa macrocarpa (Eckl.) A. DC. aerial parts on some non-communicable diseases: in vitro study and HPLC-QTOF/MS-MS analysis

DM Ghanem, NM Ammar, SS El-Hawary… - Discover Applied …, 2024 - Springer
Carissa species are evergreen plants that have long been employed in treating different
diseases by traditional healers in many cultures. Carissa macrocarpa (Eckl.) A. DC. known …

Hematological and Serum Biochemical Evaluation of Doxorubicin Induced Toxicity in Wistar Male Rats and its Amelioration with Hesperidin

RD Kondampati, UR Matukumalli… - Journal of Animal …, 2024 - search.proquest.com
Doxorubicin (DOX), an anthracycline antibiotic is used successfully to treat a variety of
cancers. The present study was designed to evaluate protective role of hesperidin, a …