Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

In the past decade, the diversity of signals generated by the ubiquitin system has emerged
as a dominant regulator of biological processes and propagation of information in the …

Glial cells constitute without any dispute an essential element in providing an efficiently
operating nervous system. Work in many labs over the last decades has demonstrated that …

Animals are able to move and react in manifold ways to external stimuli. Thus,
environmental stimuli need to be detected, information must be processed, and, finally, an …

In the central nervous system (CNS), functional tasks are often allocated to distinct
compartments. This is also evident in the Drosophila CNS where synapses and dendrites …

Abstract Morphogenesis of the Central Nervous System (CNS) is a complex process that
obeys precise architectural rules. Yet, the mechanisms dictating these rules remain …

Cell migration is an important feature of glial cells. Here, we used the Drosophila eye disc to
decipher the molecular network controlling glial migration. We stimulated glial motility by …

In Drosophila collections of green fluorescent protein (GFP) trap lines have been used to
probe the endogenous expression patterns of trapped genes or the subcellular localization …

Efficient neuronal conductance requires that axons are insulated by glial cells. For this, glial
membranes need to wrap around axons. Invertebrates show a relatively simple extension of …

In brain, the striatum is a heterogenous region involved in reward and goal-directed
behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use …