Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
The immunology of rheumatoid arthritis
CM Weyand, JJ Goronzy - Nature immunology, 2021 - nature.com
The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …
[HTML][HTML] Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
The expansion of human T-bethighCD21low B cells is T cell dependent
B Keller, V Strohmeier, I Harder, S Unger… - Science …, 2021 - science.org
Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …
activation of the adaptive immune system in certain infections and autoimmune disorders …
Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets
MK Crow - Annals of the rheumatic diseases, 2023 - ard.bmj.com
Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
Bcl6-mediated transcriptional regulation of follicular helper T cells (TFH)
Follicular helper T cells (T FH) are essential B cell-help providers in the formation of
germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity …
germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity …
Role of the CXCL13/CXCR5 axis in autoimmune diseases
Z Pan, T Zhu, Y Liu, N Zhang - Frontiers in Immunology, 2022 - frontiersin.org
CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …
Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases
H Yoshitomi, H Ueno - Cellular & molecular immunology, 2021 - nature.com
The interactions of CD4+ T cells and B cells are fundamental for the generation of protective
antibody responses, as well as for the development of harmful autoimmune diseases …
antibody responses, as well as for the development of harmful autoimmune diseases …
Clonally expanded, thyrotoxic effector CD8+ T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis
MG Lechner, Z Zhou, AT Hoang, N Huang… - Science translational …, 2023 - science.org
Autoimmune toxicity occurs in up to 60% of patients treated with immune checkpoint inhibitor
(ICI) therapy for cancer and represents an increasing clinical challenge for expanding the …
(ICI) therapy for cancer and represents an increasing clinical challenge for expanding the …
T peripheral helper cells in autoimmune diseases
Pathologic T cell–B cell interactions underlie many autoimmune diseases. The T cells that
help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical …
help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical …