Neutrophils are essential for killing bacteria and other microorganisms, and they also have a
significant role in regulating the inflammatory response. Stimulated neutrophils activate their …

Myeloperoxidase (MPO) is recognised to play important roles both in the immune system
and during the development of numerous human pathologies. MPO is released by activated …

Introduction Neutrophil accumulation is a well-established feature of Alzheimer's disease
(AD) and has been linked to cognitive impairment by modulating disease-relevant …

Thiocyanate (SCN) functions in host defense as part of the secreted lactoperoxidase (LPO)
microbicidal pathway. SCN is the preferred substrate for LPO-driven catalytic reduction of …

Myeloperoxidase (MPO) is a prominent mammalian heme peroxidase and a fundamental
component of the innate immune response against microbial pathogens. In recent times …

Myeloperoxidase is an important heme enzyme released by activated leukocytes that
catalyzes the reaction of hydrogen peroxide with halide and pseudo-halide ions to form …

Streptococcus pneumoniae is the leading cause of community-acquired pneumonia,
resulting in more than one million deaths each year worldwide. This pathogen generates …

Thiocyanate (SCN−) is a ubiquitous molecule in mammalian biology, reaching up to mM
concentrations in extracellular fluids. Two-electron oxidation of SCN− by H2O2 produces …

Hypothiocyanous acid (HOSCN) is produced in biological systems by the peroxidase-
catalyzed reaction of thiocyanate (SCN–) with H2O2. This oxidant plays an important role in …

Streptococcus pneumoniae is a serious human respiratory pathogen. It generates hydrogen
peroxide (H2O2) as part of its normal metabolism, yet it lacks enzymes that remove this …