MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

c-MYC is one of the most essential transcriptional factors, regulating a diverse array of
cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is …

High-grade B-cell lymphomas (HGBLs) with MYC and BCL2 and/or BCL6 rearrangements,
so-called “double-hit” lymphomas (HGBL-DH), are aggressive lymphomas that form a …

Transcription factors (TFs) regulate many cellular processes and can therefore serve as
readouts of the signaling and regulatory state. Yet for many TFs, the mode of action …

Inhibition of the B-cell receptor pathway, and specifically of Bruton tyrosine kinase (BTK), is a
leading therapeutic strategy in B-cell malignancies, including chronic lymphocytic leukemia …

Coronavirus replication is closely associated with the endoplasmic reticulum (ER), the
primary cellular organelle for protein synthesis, folding, and modification. ER stress is a …

RNA-binding proteins (RBPs) regulate fundamental processes, such as differentiation and
self-renewal, by enabling the dynamic control of protein abundance or isoforms or through …

Dysregulation of messenger RNA (mRNA) translation, including preferential translation of
mRNA with complex 5′ untranslated regions such as the MYC oncogene, is recognized as …

Targeted deletion of Raptor, a component of mechanistic target of rapamycin complex 1
(mTORC1), reveals an essential role for mTORC1 in initiation/maintenance of leukemia in a …

The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …