[HTML][HTML] Alleviating anxiety and taming trauma: novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder

N Singewald, SB Sartori, A Reif, A Holmes - Neuropharmacology, 2023 - Elsevier
Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …

Histone Deacetylases (HDACs) Roles in Inflammation-mediated Diseases; Current Knowledge

SA Jasim, FMA Altalbawy, M Abohassan… - Cell Biochemistry and …, 2024 - Springer
The histone acetyl transferases (HATs) and histone deacetylases (HDACs), which are
mostly recognized for their involvement in regulating chromatin remodeling via histone …

The emerging complexity of molecular pathways implicated in mouse self-grooming behavior

AN Ikrin, AM Moskalenko, RR Mukhamadeev… - Progress in Neuro …, 2023 - Elsevier
Rodent self-grooming is an important complex behavior, and its deficits are translationally
relevant to a wide range of neuropsychiatric disorders. Here, we analyzed a comprehensive …

Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short-but not long-term in a rat model of posttraumatic stress disorder.

Z Ghofrani-Jahromi, S Nouri-Darehno… - Behavioral …, 2024 - psycnet.apa.org
Psilocybe cubensis is a species of psilocybin mushroom (magic mushroom) of moderate
potency whose principal active compounds are psilocybin and psilocin. Recent studies have …

Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders

IS Palamarchuk, GM Slavich, T Vaillancourt, TK Rajji - BMC neuroscience, 2023 - Springer
In this narrative review, we examine biological processes linking psychological stress and
cognition, with a focus on how psychological stress can activate multiple neurobiological …

[HTML][HTML] The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases

RE Bonomi, W Riordan, JG Gelovani - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Over the past two decades, epigenetic regulation has become a rapidly growing and
influential field in biology and medicine. One key mechanism involves the acetylation and …

Epigenetics of violence against women: a systematic review of the literature

P Bailo, A Piccinini, G Barbara, P Caruso… - Environmental …, 2024 - academic.oup.com
Violence against women is a pervasive global issue with profound impacts on victims' well-
being, extending across cultural boundaries. Besides immediate physical harm, it triggers …

Role of Epigenetic Modification in the Intergeneration Transmission of War Trauma

A Bolouki - Indian Journal of Clinical Biochemistry, 2024 - Springer
War trauma has been linked to changes in the neuroendocrine and immunological systems
and increases the risk of physical disorders. Traumatic events during the war may have long …

Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD

KA Fisher, H Kiziah… - Case Reports in …, 2022 - Wiley Online Library
Posttraumatic stress disorder (PTSD) is a debilitating stress disorder occurring in the context
of a traumatic event and is characterized by intrusive and avoidance symptoms, negative …

[HTML][HTML] EPIGENETIC CHANGES IN POST-TRAUMATIC STRESS DISORDER: POSSIBILITIES AND LIMITATIONS OF EPIGENETIC THERAPY

IO Suchkova, EL Patkin, SG Tsikunov… - Medical academic …, 2024 - journals.eco-vector.com
The review describes epigenetic mechanisms that may contribute to individual differences in
resistance and risk of developing post-traumatic stress disorder. The review provides data …