Multiple sclerosis and myelin basic protein: Insights into protein disorder and disease
V Martinsen, P Kursula - Amino Acids, 2022 - Springer
Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.
MBP has long been studied as a factor in the pathogenesis of the autoimmune …
MBP has long been studied as a factor in the pathogenesis of the autoimmune …
Histone citrullination: a new target for tumors
D Zhu, Y Zhang, S Wang - Molecular Cancer, 2021 - Springer
As the main protein components of chromatin, histones play central roles in gene regulation
as spools of winding DNA. Histones are subject to various modifications, including …
as spools of winding DNA. Histones are subject to various modifications, including …
Will the real multiple sclerosis please stand up?
PK Stys, GW Zamponi, J Van Minnen… - Nature Reviews …, 2012 - nature.com
Multiple sclerosis (MS) is considered to be an autoimmune, inflammatory disease of the
CNS. In most patients, the disease follows a relapsing–remitting course and is characterized …
CNS. In most patients, the disease follows a relapsing–remitting course and is characterized …
Immunology of multiple sclerosis
M Sospedra, R Martin - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing
genetic trait and probably requires an inciting environmental insult such as a viral infection …
genetic trait and probably requires an inciting environmental insult such as a viral infection …
[HTML][HTML] Chemical biology of protein arginine modifications in epigenetic regulation
J Fuhrmann, KW Clancy, PR Thompson - Chemical reviews, 2015 - ACS Publications
Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease
ER Vossenaar, AJW Zendman, WJ van Venrooij… - …, 2003 - Wiley Online Library
Abstract Peptidylarginine deiminase (PAD, EC 3.5. 3.15) enzymes catalyze the conversion
of protein‐bound arginine to citrulline. This post‐translational modification may have a big …
of protein‐bound arginine to citrulline. This post‐translational modification may have a big …
Protein arginine deiminases and associated citrullination: physiological functions and diseases associated with dysregulation
EE Witalison, PR Thompson… - Current drug targets, 2015 - ingentaconnect.com
Human proteins are subjected to more than 200 known post-translational modifications
(PTMs)(eg, phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation …
(PTMs)(eg, phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation …
Activation of PAD4 in NET formation
AS Rohrbach, DJ Slade, PR Thompson… - Frontiers in …, 2012 - frontiersin.org
Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally
encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in …
encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in …
Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis
S Wang, Y Wang - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2013 - Elsevier
Peptidylarginine deiminases are a family of enzymes that mediate post-translational
modifications of protein arginine residues by deimination or demethylimination to produce …
modifications of protein arginine residues by deimination or demethylimination to produce …
Citrullination: a posttranslational modification in health and disease
Posttranslational modifications are chemical changes to proteins that take place after
synthesis. One such modification, peptidylarginine to peptidylcitrulline conversion, catalysed …
synthesis. One such modification, peptidylarginine to peptidylcitrulline conversion, catalysed …