Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which
can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti …

Background & Objective: Chagas disease or American trypanosomiasis is a major parasitic
disease in Latin America with restricted available treatment: nifurtimox and benznidazole …

Quinones are attractive pharmacological scaffolds for developing new agents for the
treatment of different transmissible and non-transmissible human diseases due to their …

Chalcones are a group of molecules with a broad spectrum of biological activities, being
especially appealing for their antiproliferative effects on several cancer cell lines. For this …

Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …

A set of new aryloxy-quinones were synthesized and evaluated in vitro against the
epimastigote form of Trypanosoma cruzi and their unspecific cytotoxicity was tested on …

In the search for new therapeutic alternatives for Chagas disease, a series of six aryloxy-
naphthoquinone derivatives were synthesized and evaluated in vitro against Trypanosoma …

Chagas disease is a so-called “neglected disease” and endemic to Latin America.
Nifurtimox and benznidazole are drugs that have considerable efficacy in the treatment of …

Continuing with a program to develop new quinone derivatives as biologically active
compounds, we designed and synthesized a new series of aryloxy‐quinones, which were …

In continuation our effort to research the chemical space of aryloxy-naphthoquinones as
potential anti-Chagas agents, we synthesized nine derivatives and these compounds were …