Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

Spina bifida is a birth defect in which the vertebral column is open, often with spinal cord
involvement. The most clinically significant subtype is myelomeningocele (open spina …

The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables
the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might …

Background Neural tube defects (NTDs) are debilitating birth defects involving the central
nervous system (CNS). Despite recent advances, NTDs represent the second most common …

Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Planar cell polarity (PCP), the orientation and alignment of cells within a sheet, is a
ubiquitous cellular property that is commonly governed by the conserved set of proteins …

Folate (vitamin B9) is widely accepted to protect against fetal neural tube defects. The main
sources of dietary folate are folic acid-fortified foods and folic acid-containing dietary …

Improving nutritional health is one of the major socio-economic challenges of the 21st
century, especially with the continuously growing and ageing world population. Folate …

Abstract Background Neural tube defects (NTDs) are one of the most severe congenital
abnormalities characterized by failures of the neural tube to close during early …