[HTML][HTML] A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins
AG Kikhney, DI Svergun - FEBS letters, 2015 - Elsevier
Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
Nerve growth factor: early studies and recent clinical trials
ML Rocco, M Soligo, L Manni… - Current …, 2018 - ingentaconnect.com
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in
developmental and adult neurobiology for its many important regulatory functions on the …
developmental and adult neurobiology for its many important regulatory functions on the …
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering
P Bernado, DI Svergun - Molecular biosystems, 2012 - pubs.rsc.org
Small-angle scattering of X-rays (SAXS) is an established method to study the overall
structure and structural transitions of biological macromolecules in solution. For folded …
structure and structural transitions of biological macromolecules in solution. For folded …
NGF steers microglia toward a neuroprotective phenotype
Microglia are the sentinels of the brain but a clear understanding of the factors that modulate
their activation in physiological and pathological conditions is still lacking. Here we …
their activation in physiological and pathological conditions is still lacking. Here we …
Molecular and structural insight into proNGF engagement of p75NTR and sortilin
Nerve growth factor (NGF) is initially synthesized as a precursor, proNGF, that is cleaved to
release its C-terminal mature form. Recent studies suggested that proNGF is not an inactive …
release its C-terminal mature form. Recent studies suggested that proNGF is not an inactive …
Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis
A Cattaneo, P Calissano - Molecular neurobiology, 2012 - Springer
Understanding sporadic Alzheimer's disease (AD) onset and progression requires an
explanation of what triggers the common core of abnormal processing of the amyloid …
explanation of what triggers the common core of abnormal processing of the amyloid …
Fast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands
L Marchetti, F Bonsignore, F Gobbo… - Proceedings of the …, 2019 - National Acad Sciences
The p75 neurotrophin (NT) receptor (p75NTR) plays a crucial role in balancing survival-
versus-death decisions in the nervous system. Yet, despite 2 decades of structural and …
versus-death decisions in the nervous system. Yet, despite 2 decades of structural and …
Taking pain out of NGF: a “painless” NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity
During adulthood, the neurotrophin Nerve Growth Factor (NGF) sensitizes nociceptors,
thereby increasing the response to noxious stimuli. The relationship between NGF and pain …
thereby increasing the response to noxious stimuli. The relationship between NGF and pain …
ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice
ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of
NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction …
NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction …
Mechanisms and regulation of neurotrophin synthesis and secretion
MA Al-Qudah, A Al-Dwairi - Neurosciences Journal, 2016 - nsj.org.sa
Neurotrophins are secreted proteins that are synthesized as pre-pro-neurotrophins on the
rough endoplasmic reticulum, which are subsequently processed and then secreted as …
rough endoplasmic reticulum, which are subsequently processed and then secreted as …