[HTML][HTML] Multiple nano-drug delivery systems for intervertebral disc degeneration: Current status and future perspectives

W Liu, Z Ma, Y Wang, J Yang - Bioactive Materials, 2023 - Elsevier
Low back pain (LBP) is a common disease that imposes a huge social and economic
burden on people. Intervertebral disc (IVD) degeneration (IVDD) is often considered to be …

Non-specific low back pain

F Balagué, AF Mannion, F Pellisé, C Cedraschi - The lancet, 2012 - thelancet.com
Non-specific low back pain has become a major public health problem worldwide. The
lifetime prevalence of low back pain is reported to be as high as 84%, and the prevalence of …

[HTML][HTML] Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

F Wang, F Cai, R Shi, XH Wang, XT Wu - Osteoarthritis and cartilage, 2016 - Elsevier
Intervertebral disc (IVD) degeneration is a complicated process that involves both age-
related change and tissue damage caused by multiple stresses. In a degenerative IVD …

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

D Sakai, GBJ Andersson - Nature Reviews Rheumatology, 2015 - nature.com
Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain,
which accounts for disability worldwide. Despite the known outcomes of the IVD …

Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

G Livshits, M Popham, I Malkin, PN Sambrook… - Annals of the …, 2011 - ard.bmj.com
Objective Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear
which individuals develop it. The authors examined the contribution of genetic factors …

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain

AJ Freemont - Rheumatology, 2009 - academic.oup.com
In 2007, three times as many peer reviewed publications covering the biology and
biotherapeutics of intervertebral disc (IVD) disease appeared in the literature than in 1997 …

Unraveling the complexity of low back pain

P O'Sullivan, JP Caneiro, M O'Keeffe… - Journal of Orthopaedic & …, 2016 - jospt.org
Low back pain (LBP) is the leading cause of disability worldwide. Various approaches to
diagnose and manage LBP have arisen, leading to an exponential increase in health care …

[图书][B] The Biomechanics of Back Pain-E-Book

MA Adams, N Bogduk, K Burton, P Dolan - 2012 - books.google.com
Authored by experts of international renown, the new edition of The Biomechanics of Back
Pain forms a bridge between the latest research and the effective clinical management of …

[HTML][HTML] Genetic predictors of human chronic pain conditions

K Zorina-Lichtenwalter, CB Meloto, S Khoury… - Neuroscience, 2016 - Elsevier
Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: a systematic review of twin …

AB Dario, ML Ferreira, KM Refshauge, TS Lima… - The spine journal, 2015 - Elsevier
Background context The relationships between obesity and low back pain (LBP) and lumbar
disc degeneration (LDD) remain unclear. It is possible that familial factors, including …