Frog skin innate immune defences: sensing and surviving pathogens

JFA Varga, MP Bui-Marinos… - Frontiers in …, 2019 - frontiersin.org
Amphibian skin is a mucosal surface in direct and continuous contact with a microbially
diverse and laden aquatic and/or terrestrial environment. As such, frog skin is an important …

Review of the amphibian immune response to chytridiomycosis, and future directions

LF Grogan, J Robert, L Berger, LF Skerratt… - Frontiers in …, 2018 - frontiersin.org
The fungal skin disease, chytridiomycosis (caused by Batrachochytrium dendrobatidis and
B. salamandrivorans), has caused amphibian declines and extinctions globally since its …

Microbiota and mucosal immunity in amphibians

BM Colombo, T Scalvenzi, S Benlamara… - Frontiers in …, 2015 - frontiersin.org
We know that animals live in a world dominated by bacteria. In the last 20 years, we have
learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and …

The adaptive microbiome hypothesis and immune interactions in amphibian mucus

DC Woodhams, J McCartney, JB Walke… - Developmental & …, 2023 - Elsevier
The microbiome is known to provide benefits to hosts, including extension of immune
function. Amphibians are a powerful immunological model for examining mucosal defenses …

Environmental fluctuations and host skin bacteria shift survival advantage between frogs and their fungal pathogen

AV Longo, KR Zamudio - The ISME journal, 2017 - academic.oup.com
Fluctuating environments can modulate host–pathogen interactions by providing a
temporary advantage to one of the interacting organisms. However, we know very little about …

Amphibian skin microbiota exhibits temporal variation in community structure but stability of predicted Bd-inhibitory function

MC Bletz, RGB Perl, BTC Bobowski, LM Japke… - The ISME …, 2017 - academic.oup.com
Host-associated microbiomes are increasingly recognized to contribute to host disease
resistance; the temporal dynamics of their community structure and function, however, are …

Thermal cues drive plasticity of desiccation resistance in montane salamanders with implications for climate change

EA Riddell, EY Roback, CE Wells, KR Zamudio… - Nature …, 2019 - nature.com
Organisms rely upon external cues to avoid detrimental conditions during environmental
change. Rapid water loss, or desiccation, is a universal threat for terrestrial plants and …

Fungal disease and temperature alter skin microbiome structure in an experimental salamander system

CR Muletz‐Wolz, RC Fleischer, KR Lips - Molecular Ecology, 2019 - Wiley Online Library
Pathogens compete with host microbiomes for space and resources. Their shared
environment impacts pathogen–microbiome–host interactions, which can lead to variation in …

Immunological aspects of chytridiomycosis

LF Grogan, JE Humphries, J Robert, CM Lanctôt… - Journal of Fungi, 2020 - mdpi.com
Amphibians are currently the most threatened vertebrate class, with the disease
chytridiomycosis being a major contributor to their global declines. Chytridiomycosis is a …

Gene expression differs in susceptible and resistant amphibians exposed to Batrachochytrium dendrobatidis

EA Eskew, BC Shock… - Royal Society …, 2018 - royalsocietypublishing.org
Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium
dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts …