The role of gamma oscillations in central nervous system diseases: Mechanism and treatment
A Guan, S Wang, A Huang, C Qiu, Y Li, X Li… - Frontiers in cellular …, 2022 - frontiersin.org
Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural
oscillations, which are rhythmic electric processes of neuron groups in the brain. The …
oscillations, which are rhythmic electric processes of neuron groups in the brain. The …
Epileptogenesis in tuberous sclerosis complex-related developmental and epileptic encephalopathy
E Aronica, N Specchio, MJ Luinenburg, P Curatolo - Brain, 2023 - academic.oup.com
Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …
Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice
S Yao, MD Xu, Y Wang, ST Zhao, J Wang… - Nature …, 2023 - nature.com
Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …
Negative effects of brain regulatory T cells depletion on epilepsy
J Yue, R Xu, C Yin, H Yang, C Zhang, D Zhao - Progress in Neurobiology, 2022 - Elsevier
The infiltration of immune cells is observed in the epileptogenic zone; however, the
relationship between epilepsy and regulatory T cells (Tregs) remains only partially …
relationship between epilepsy and regulatory T cells (Tregs) remains only partially …
Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
Y Zhang, H Zong, Y Qi, L Chang, Y Gao, T Zhou… - Molecular …, 2023 - nature.com
Diabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a
lower prevalence of anxiety disorders, yet the precise mechanism behind this phenomenon …
lower prevalence of anxiety disorders, yet the precise mechanism behind this phenomenon …
Neddylation of protein, a new strategy of protein post-translational modification for targeted treatment of central nervous system diseases
Q Wu, Z Geng, J Lu, S Wang, Z Yu, S Wang… - Frontiers in …, 2024 - frontiersin.org
Neddylation, a type of protein post-translational modification that links the ubiquitin-like
protein NEDD8 to substrate proteins, can be involved in various significant cellular …
protein NEDD8 to substrate proteins, can be involved in various significant cellular …
Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS
Y Jo, J Lee, SY Lee, I Kwon… - Proceedings of the …, 2022 - National Acad Sciences
Expansion of the GGGGCC hexanucleotide repeat in the chromosome 9 open reading frame
72 (C9orf72) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) …
72 (C9orf72) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) …
ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity
The precise control of the nervous system function under the vitality of synapses is extremely
critical. Efforts have been taken to explore the underlying cellular and molecular …
critical. Efforts have been taken to explore the underlying cellular and molecular …
Neddylation steers the fate of cellular receptors
JB Park, MY Lee, J Lee, GH Moon, SJ Kim… - … & Molecular Medicine, 2024 - nature.com
Cellular receptors regulate physiological responses by interacting with ligands, thus playing
a crucial role in intercellular communication. Receptors are categorized on the basis of their …
a crucial role in intercellular communication. Receptors are categorized on the basis of their …
Deneddylating enzyme SENP8 regulates neuronal development
J Song, M Kang, S Lee, J Kim, S Park… - Journal of …, 2023 - Wiley Online Library
Neddylation is a cellular process in which the neural precursor cell expressed,
developmentally down‐regulated 8 (NEDD8) is conjugated to the lysine residue of target …
developmentally down‐regulated 8 (NEDD8) is conjugated to the lysine residue of target …