The role of gamma oscillations in central nervous system diseases: Mechanism and treatment

A Guan, S Wang, A Huang, C Qiu, Y Li, X Li… - Frontiers in cellular …, 2022 - frontiersin.org
Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural
oscillations, which are rhythmic electric processes of neuron groups in the brain. The …

Epileptogenesis in tuberous sclerosis complex-related developmental and epileptic encephalopathy

E Aronica, N Specchio, MJ Luinenburg, P Curatolo - Brain, 2023 - academic.oup.com
Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

S Yao, MD Xu, Y Wang, ST Zhao, J Wang… - Nature …, 2023 - nature.com
Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

Negative effects of brain regulatory T cells depletion on epilepsy

J Yue, R Xu, C Yin, H Yang, C Zhang, D Zhao - Progress in Neurobiology, 2022 - Elsevier
The infiltration of immune cells is observed in the epileptogenic zone; however, the
relationship between epilepsy and regulatory T cells (Tregs) remains only partially …

Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons

Y Zhang, H Zong, Y Qi, L Chang, Y Gao, T Zhou… - Molecular …, 2023 - nature.com
Diabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a
lower prevalence of anxiety disorders, yet the precise mechanism behind this phenomenon …

Neddylation of protein, a new strategy of protein post-translational modification for targeted treatment of central nervous system diseases

Q Wu, Z Geng, J Lu, S Wang, Z Yu, S Wang… - Frontiers in …, 2024 - frontiersin.org
Neddylation, a type of protein post-translational modification that links the ubiquitin-like
protein NEDD8 to substrate proteins, can be involved in various significant cellular …

Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS

Y Jo, J Lee, SY Lee, I Kwon… - Proceedings of the …, 2022 - National Acad Sciences
Expansion of the GGGGCC hexanucleotide repeat in the chromosome 9 open reading frame
72 (C9orf72) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) …

ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity

B Luo, Z Liu, D Lin, W Chen, D Ren, Z Yu… - Translational …, 2021 - nature.com
The precise control of the nervous system function under the vitality of synapses is extremely
critical. Efforts have been taken to explore the underlying cellular and molecular …

Neddylation steers the fate of cellular receptors

JB Park, MY Lee, J Lee, GH Moon, SJ Kim… - … & Molecular Medicine, 2024 - nature.com
Cellular receptors regulate physiological responses by interacting with ligands, thus playing
a crucial role in intercellular communication. Receptors are categorized on the basis of their …

Deneddylating enzyme SENP8 regulates neuronal development

J Song, M Kang, S Lee, J Kim, S Park… - Journal of …, 2023 - Wiley Online Library
Neddylation is a cellular process in which the neural precursor cell expressed,
developmentally down‐regulated 8 (NEDD8) is conjugated to the lysine residue of target …