Recent advances in synthetic strategies and SAR of thiazolidin-4-one containing molecules in cancer therapeutics

A Sharma, D Sharma, N Saini, SV Sharma… - Cancer and Metastasis …, 2023 - Springer
Cancer is one of the life-threatening diseases accountable for millions of demises globally.
The inadequate effectiveness of the existing chemotherapy and its harmful effects has …

Design, synthesis, and anticancer activity of novel 4-thiazolidinone-phenylaminopyrimidine hybrids

A Türe, M Ergül, M Ergül, A Altun, İ Küçükgüzel - Molecular Diversity, 2021 - Springer
Thiazolidinones and phenylaminopyrimidines are known as anticancer agents. Imatinib is
the pioneer phenylaminopyrimidine derivative kinase inhibitor, which is used for the …

Novel 4‐Thiazolidinone Derivatives as Anti‐Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation

A Gupta, R Singh, PK Sonar… - Biochemistry research …, 2016 - Wiley Online Library
A series of new 4‐thiazolidinone derivatives was synthesized, characterized by spectral
techniques, and screened for antimicrobial activity. All the compounds were evaluated …

Synthesis, Cytotoxicity, and Pro‐Apoptosis Activity of Etodolac Hydrazide Derivatives as Anticancer Agents

P Çıkla, D Özsavcı, Ö Bingöl‐Özakpınar… - Archiv der …, 2013 - Wiley Online Library
Etodolac hydrazide and a novel series of etodolac hydrazide‐hydrazones 3–15 and
etodolac 4‐thiazolidinones 16–26 were synthesized in this study. The structures of the new …

2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase

İ Küçükgüzel, G Satılmış, KR Gurukumar, A Basu… - European Journal of …, 2013 - Elsevier
Abstract Hepatitis C virus (HCV) NS5B polymerase is an important and attractive target for
the development of anti-HCV drugs. Here we report on the design, synthesis and evaluation …

Novel 4‐thiazolidinones as non‐nucleoside inhibitors of hepatitis C virus NS5B RNA‐dependent RNA polymerase

G Çakır, İ Küçükgüzel, R Guhamazumder… - Archiv der …, 2015 - Wiley Online Library
In continuation of our efforts to develop new derivatives as hepatitis C virus (HCV) NS5B
inhibitors, we synthesized novel 5‐arylidene‐4‐thiazolidinones. The novel compounds 29 …

Synthesis and characterization of flurbiprofen hydrazide derivatives as potential anti-HCV, anticancer and antimicrobial agents

P Çıkla, E Tatar, İ Küçükgüzel, F Şahin… - Medicinal Chemistry …, 2013 - Springer
A novel series of new flurbiprofen hydrazide derivatives 2-(2-fluorobiphenyl-4-yl)-N′-
[(substituted phenyl/5-nitro-2-furyl) methylene] propanehydrazide (3a–k), 2-(2-fluorobiphenyl …

Synthesis and biological evaluation of some new 1, 3, 4-thiadiazole and 1, 2, 4-triazole derivatives from L-methionine as antituberculosis and antiviral agents

E Tatar, Ş Küçükgüzel, S Karakuş… - Marmara …, 2015 - dergipark.org.tr
Some novel 1, 3, 4-thiadiazole [5-8] and 1, 2, 4-triazole [9-12] derivatives carrying amino
acid moiety were synthesized starting from L-methionine. 1, 3, 4-Thiadiazole and 1, 2, 4 …

New 4-thiazolidinones from 5-ethyl pyridine-2-ethanol: Their antibacterial, antifungal, and antitubercular activity

NB Patel, HR Patel, FM Shaikh, D Rajani - Medicinal Chemistry Research, 2014 - Springer
New thiazolidinones 5a–o were prepared from Schiff base 4a–o and thioglycolic acid in the
presence of ZnCl 2 from 4-[2-(5-ethylpyridin-2-yl) ethoxy] benzaldehyde. The structures of …

Synthesis, antimycobacterial, cytotoxicity, anti‐inflammatory, in silico studies and molecular dynamics of pyrazole‐embedded thiazolidin‐4‐one hybrids

V Kamat, B Poojary, D Puthran, VB Das… - Archiv der …, 2023 - Wiley Online Library
In the present investigation, we devolved and synthesized a new series of pyrazole‐
embedded thiazolidin‐4‐one derivatives (9a–p) with the goal to produce promising …