Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …

Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

We identified emerging scientific, technological, and sociopolitical issues likely to affect how
biological invasions are studied and managed over the next two decades. Issues were …

We present tRNA-based vectors for producing multiple clustered regularly interspaced short
palindromic repeats (CRISPR) single guide RNAs (sgRNAs) from a single RNA polymerase …

I consider how the study of genetic variation has influenced efforts to conserve natural
populations over the last 50 years. Studies with allozymes in the 1970s provided the first …

Abstract The 2019 United Nations Global assessment report on biodiversity and ecosystem
services estimated that approximately 1 million species are at risk of extinction. This …

Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …

A functioning gene drive system could fundamentally change our strategies for the control of
vector-borne diseases by facilitating rapid dissemination of transgenes that prevent …

CRISPR/Cas9 gene drive (CGD) promises to be a highly adaptable approach for spreading
genetically engineered alleles throughout a species, even if those alleles impair …

The increasing use of engineered organisms for industrial, clinical, and environmental
applications poses a growing risk of spreading hazardous biological entities into the …