Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted …

Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The
mechanism of their action in B cells of the pancreas has been intensively investigated and …

Administration of both streptozotocin (STZ) and nicotinamide (NA) has been proposed to
induce experimental diabetes in the rat. STZ is well known to cause pancreatic B-cell …

Recent evidence is reviewed indicating increased oxidative damage in Type 1 and Type 2
diabetes mellitus as well as deficits in antioxidant defence enzymes and vitamins …

This review summarises the results and discussions of an UNESCO‐MCBN supported
symposium on oxidative stress and its role in the onset and progression of diabetes. There is …

Alzheimer's disease remains incurable, and the failures of current disease-modifying
strategies for Alzheimer's disease could be attributed to a lack of in vivo models that …

Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD).
Most AD cases are sporadic and result from multiple etiologic factors, including …

Diabetes mellitus type 1 and 2 (T1DM and T2DM) are complex multifactorial diseases. Loss
of beta-cell function caused by reduced secretory capacity and enhanced apoptosis is a key …

Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea
derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic …

We hypothesized that oxygen free radicals (OFRs) may be involved in pathogenesis of
diabetic complications. We therefore investigated the levels of lipid peroxidation by …