An overview of CDK3 in cancer: clinical significance and pharmacological implications

T Teo, S Kasirzadeh, H Albrecht, MJ Sykes… - Pharmacological …, 2022 - Elsevier
Abstract Cyclin-dependent kinase 3 (CDK3) is a major player driving retinoblastoma (Rb)
phosphorylation during the G 0/G 1 transition and in the early G 1 phase of the cell cycle …

Adapter proteins for opposing motors interact simultaneously with nuclear pore protein Nup358

H Cui, CR Noell, RP Behler, JB Zahn, LR Terry… - Biochemistry, 2019 - ACS Publications
Nup358 is a protein subunit of the nuclear pore complex that recruits the opposing
microtubule motors kinesin-1 and dynein [via the dynein adaptor Bicaudal D2 (BicD2)] to the …

A quantitative model for BicD2/cargo interactions

CR Noell, KM Loftus, H Cui, C Grewer, M Kizer… - Biochemistry, 2018 - ACS Publications
Dynein adaptor proteins such as Bicaudal D2 (BicD2) are integral components of the dynein
transport machinery, as they recognize cargoes for cell cycle-specific transport and link them …

Coiled‐coil registry shifts in the F684I mutant of Bicaudal D result in cargo‐independent activation of dynein motility

H Cui, MY Ali, P Goyal, K Zhang, JY Loh, KM Trybus… - Traffic, 2020 - Wiley Online Library
Abstract The dynein adaptor Drosophila Bicaudal D (BicD) is auto‐inhibited and activates
dynein motility only after cargo is bound, but the underlying mechanism is elusive. In …

Molecular mechanism for recognition of the cargo adapter Rab6GTP by the dynein adapter BicD2

X Zhao, S Quintremil, EDR Castro, H Cui… - Life Science …, 2024 - life-science-alliance.org
Rab6 is a key modulator of protein secretion. The dynein adapter Bicaudal D2 (BicD2)
recruits the motors cytoplasmic dynein and kinesin-1 to Rab6GTP-positive vesicles for …

RETRACTED: PIMREG, a Marker of Proliferation, Facilitates Aggressive Development of Cholangiocarcinoma Cells Partly Through Regulating Cell Cycle-Related …

ZM Jiang, HB Li, SG Chen - Technology in Cancer …, 2020 - journals.sagepub.com
Background: Phosphatidylinositol binding clathrin assembly protein interacting mitotic
regulator (PIMREG) is a protein associated with cell proliferation. Its aberrant expression …

Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders

J Yi, X Zhao, CR Noell, P Helmer, SR Solmaz… - PLoS …, 2023 - journals.plos.org
Bicaudal D2 (BICD2) is responsible for recruiting cytoplasmic dynein to diverse forms of
subcellular cargo for their intracellular transport. Mutations in the human BICD2 gene have …

Positive selection-driven fixation of a hominin-specific amino acid mutation related to dephosphorylation in IRF9

J Chen, X He, I Jakovlić - BMC Ecology and Evolution, 2022 - Springer
The arms race between humans and pathogens drives the evolution of the human genome.
It is thus expected that genes from the interferon-regulatory factors family (IRFs), a critical …

Mechanistic Insights into Auto-Inhibition of the Dynein Adaptor Bicaudal D

H Cui - 2022 - search.proquest.com
Cytoplasmic dynein is a motor protein complex that transports cargoes to the minus-end of
microtubules. Dynein adaptors such as human Bicaudal D2 (Hs BicD2) and Drosophila BicD …

Investigating Cargo-Recognition and Activation of Dynein Adapter Protein BicD2 and Its Role in Neuromuscular Diseases

CR Noell - 2021 - search.proquest.com
The nucleoporin Nup358 is a subunit of the nuclear pore complex (NPC) that recruits the
dynein adapter protein Bicaudal D2 (BicD2) to NPCs. BicD2 in turn recruits the dynein …