Antimicrobial peptides: A new hope in biomedical and pharmaceutical fields

A Moretta, C Scieuzo, AM Petrone, R Salvia… - Frontiers in cellular …, 2021 - frontiersin.org
Antibiotics are essential drugs used to treat pathogenic bacteria, but their prolonged use
contributes to the development and spread of drug-resistant microorganisms. Antibiotic …

[HTML][HTML] Antimicrobial peptides: an emerging category of therapeutic agents

M Mahlapuu, J Håkansson, L Ringstad… - Frontiers in cellular and …, 2016 - frontiersin.org
Antimicrobial peptides (AMPs), also known as host defense peptides, are short and
generally positively charged peptides found in a wide variety of life forms from …

Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?

MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …

Mechanisms and regulation of defensins in host defense

J Fu, X Zong, M Jin, J Min, F Wang… - Signal Transduction and …, 2023 - nature.com
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Antimicrobial peptides in 2014

G Wang, B Mishra, K Lau, T Lushnikova, R Golla… - Pharmaceuticals, 2015 - mdpi.com
This article highlights new members, novel mechanisms of action, new functions, and
interesting applications of antimicrobial peptides reported in 2014. As of December 2014 …

Perspectives for clinical use of engineered human host defense antimicrobial peptides

ME Pachón-Ibáñez, Y Smani, J Pachon… - FEMS microbiology …, 2017 - academic.oup.com
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …

Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellular Salmonella enterica serovar Typhimurium

JH Yeom, B Lee, D Kim, J Lee, S Kim, J Bae, Y Park… - Biomaterials, 2016 - Elsevier
Antimicrobial peptides (AMPs) are a promising new class of antibacterial compounds.
However, their applications in the treatment of intracellular pathogenic bacteria have been …

Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections

B Lamichhane, AMM Mawad, M Saleh, WG Kelley… - Antibiotics, 2024 - mdpi.com
Salmonella is a major foodborne pathogen and a leading cause of gastroenteritis in humans
and animals. Salmonella is highly pathogenic and encompasses more than 2600 …

Mammalian antimicrobial peptides: promising therapeutic targets against infection and chronic inflammation

P Dutta, S Das - Current topics in medicinal chemistry, 2016 - ingentaconnect.com
Antimicrobial peptides (AMPs) are integral components of the host innate immune system
and functional throughout the plant and animal kingdoms. AMPs are short cationic …

Porcine beta-defensin 2 provides protection against bacterial infection by a direct bactericidal activity and alleviates inflammation via interference with the TLR4/NF-κB …

C Huang, X Yang, J Huang, X Liu, X Yang… - Frontiers in …, 2019 - frontiersin.org
Porcine beta-defensin 2 (PBD-2) which is a member of the family of antimicrobial peptides,
is widely expressed in pig organs with a broad spectrum of bactericidal activities confirmed …