MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate
gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the …

The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …

Pervasive transcription occurs in the human genome to generate thousands of RNA
transcripts, and accumulating evidence suggested that the RNA molecules, without protein …

The process of cancer metastasis involves a series of sequential and complex steps. Here
we give a perspective on recent results regarding noncoding transcription in cancer …

Oligonucleotides are designed to target RNA using base pairing rules, but they can be
hampered by poor cellular delivery and nonspecific stimulation of the immune system. Small …

Aptamers that target a specific cell subpopulation within composite mixtures represent
invaluable tools in biomedical research and in the development of cell-specific therapeutics …

Aptamers are single-stranded oligonucleotides that bind to their targets via specific structural
interactions. To improve the properties and performance of aptamers, modified nucleotides …

Recent advances in genome‐wide analysis have revealed that 66% of the genome is
actively transcribed into noncoding RNAs (ncRNAs) while less than 2% of the sequences …

MicroRNAs (miRNAs) play crucial roles in regulating gene expression in many cellular
contexts. Deregulation of miRNAs has been implicated in a number of disease conditions …