Lactococcus lactis has progressed a long way since its discovery and initial use in dairy
product fermentation, to its present biotechnological applications in genetic engineering for …

Functional and structural studies of membrane proteins usually require overexpression of
the proteins in question. Often, however, the 'trial and error'approaches that are mainly used …

Background Membrane proteins are the targets of 50% of drugs, although they only
represent 1% of total cellular proteins. The first major bottleneck on the route to their …

The lactic acid bacteria (LAB) are a functionally related group of low-GC Gram-positive
bacteria known essentially for their roles in bioprocessing of foods and animal feeds. Due to …

Mutations in SLC25A4 encoding the mitochondrial ADP/ATP carrier AAC1 are well-
recognized causes of mitochondrial disease. Several heterozygous SLC25A4 mutations …

In most plants, constitutes the major source of nitrogen, and its assimilation into amino acids
is mainly achieved in shoots. Furthermore, recent reports have revealed that reduction of …

RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …

Saccharomyces cerevisiae must import copper into the mitochondrial matrix for eventual
assembly of cytochrome c oxidase. This copper is bound to an anionic fluorescent molecule …

Roughly one-third of all proteins reside in biological membranes [1, 2]. Integral membrane
proteins (IMPs), which can only be released from the membrane by disruption of the …

Escherichia coli is by far the most widely used bacterial host for the production of membrane
proteins. Usually, different strains, culture conditions and production regimes are screened …