Magnetic resonance imaging for the diagnosis of Parkinson's disease
B Heim, F Krismer, R De Marzi, K Seppi - Journal of neural transmission, 2017 - Springer
The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …
challenging in neurology and error rates in the clinical diagnosis can be high even at …
A delicate balance: Iron metabolism and diseases of the brain
Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …
cellular processes including neurotransmitter synthesis, myelination of neurons, and …
The 'swallow tail'appearance of the healthy nigrosome–a new accurate test of Parkinson's disease: a case-control and retrospective cross-sectional MRI study at 3T
There is no well-established in vivo marker of nigral degeneration in Parkinson's disease
(PD). An ideal imaging marker would directly mirror the loss of substantia nigra …
(PD). An ideal imaging marker would directly mirror the loss of substantia nigra …
Quantifying brain iron deposition in patients with Parkinson's disease using quantitative susceptibility mapping, R2 and R2
JHO Barbosa, AC Santos, V Tumas, M Liu… - Magnetic resonance …, 2015 - Elsevier
Purpose To evaluate the sensitivity and specificity of quantitative magnetic resonance (MR)
iron mapping including R2, R2* and magnetic susceptibility to differentiate patients with …
iron mapping including R2, R2* and magnetic susceptibility to differentiate patients with …
Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature
One objective of modern neuroimaging is to identify markers that can aid in diagnosis,
disease progression monitoring and long-term drug impact analysis. In this study, Parkinson …
disease progression monitoring and long-term drug impact analysis. In this study, Parkinson …
Practical medical applications of quantitative MR relaxometry
HL Margaret Cheng, N Stikov… - Journal of Magnetic …, 2012 - Wiley Online Library
Conventional MR images are qualitative, and their signal intensity is dependent on several
complementary contrast mechanisms that are manipulated by the MR hardware and …
complementary contrast mechanisms that are manipulated by the MR hardware and …
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's …
DB Kell - Archives of toxicology, 2010 - Springer
Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …
death, often characterised by circumstances in which cells or tissues do not merely die and …
Neuromelanin imaging and dopaminergic loss in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major
pathologic substrate is a loss of dopaminergic neurons from the substantia nigra. Our main …
pathologic substrate is a loss of dopaminergic neurons from the substantia nigra. Our main …
Quantitative susceptibility mapping of the midbrain in Parkinson's disease
Background Parkinson's disease (PD) is marked pathologically by dopamine neuron loss
and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to …
and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to …
T2 mapping from highly undersampled data by reconstruction of principal component coefficient maps using compressed sensing
Recently, there has been an increased interest in quantitative MR parameters to improve
diagnosis and treatment. Parameter mapping requires multiple images acquired with …
diagnosis and treatment. Parameter mapping requires multiple images acquired with …