In vitro Models of Neurodegenerative Diseases
A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
In vitro methodologies to study the role of advanced glycation end products (AGEs) in neurodegeneration
M Chrysanthou, I Miro Estruch, IMCM Rietjens… - Nutrients, 2022 - mdpi.com
Advanced glycation end products (AGEs) can be present in food or be endogenously
produced in biological systems. Their formation has been associated with chronic …
produced in biological systems. Their formation has been associated with chronic …
Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
J Delp, A Cediel-Ulloa, I Suciu, P Kranaster… - Archives of …, 2021 - Springer
Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-
phenylpyridinium (MPP+) leads to the degeneration of dopaminergic neurons in man and …
phenylpyridinium (MPP+) leads to the degeneration of dopaminergic neurons in man and …
Three-dimensional neuroimmune co-culture system for modeling Parkinson's disease microenvironments in vitro
L Rueda-Gensini, JA Serna, D Rubio, JC Orozco… - …, 2023 - iopscience.iop.org
Parkinson's disease (PD) is a complex and multifaceted neurodegenerative disorder that
results from multiple environmental factors and multicellular interactions. Although several …
results from multiple environmental factors and multicellular interactions. Although several …
A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes
L Badenetti, R Manzoli, M Trevisan, F D'Avanzo… - Scientific Reports, 2023 - nature.com
Multiple complex intracellular cascades contributing to Hunter syndrome (
mucopolysaccharidosis type II) pathogenesis have been recognized and documented in the …
mucopolysaccharidosis type II) pathogenesis have been recognized and documented in the …
Oleanane- and Ursane-Type Triterpene Saponins from Centella asiatica Exhibit Neuroprotective Effects
ZW Wu, WB Li, J Zhou, X Liu, L Wang… - Journal of Agricultural …, 2020 - ACS Publications
Six new pentacyclic triterpenoid saponins, centelloside F (1), centelloside G (2), 11-oxo-
asiaticoside B (3), 11-oxo-madecassoside (4), 11 (β)-methoxy asiaticoside B (5), and 11 (β) …
asiaticoside B (3), 11-oxo-madecassoside (4), 11 (β)-methoxy asiaticoside B (5), and 11 (β) …
Rotenone neurotoxicity: Relevance to Parkinson's disease
Rotenone is one of the most widely used insecticide and pisicides in the US and around the
world. Epidemiological evidences suggest that rotenone exposure may be a risk factor for …
world. Epidemiological evidences suggest that rotenone exposure may be a risk factor for …
MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease
Gastrointestinal (GI) disturbances are one of the earliest symptoms affecting most patients
with Parkinson's disease (PD). In many cases, these symptoms are observed years before …
with Parkinson's disease (PD). In many cases, these symptoms are observed years before …
Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study
S Ghaisas, DS Harischandra… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Chronic environmental exposure to manganese (Mn) can cause debilitating
damage to the central nervous system. However, its potential toxic effects on the enteric …
damage to the central nervous system. However, its potential toxic effects on the enteric …
The Parkinson's disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein
JD Prahl, SE Pierce, EJC van der Schans… - Human Molecular …, 2023 - academic.oup.com
One of the most significant risk variants for Parkinson's disease (PD), rs356182, is located at
the PD-associated locus near the alpha-synuclein (α-syn) encoding gene, SNCA. SNCA …
the PD-associated locus near the alpha-synuclein (α-syn) encoding gene, SNCA. SNCA …