Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

Advanced glycation end products (AGEs) can be present in food or be endogenously
produced in biological systems. Their formation has been associated with chronic …

Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-
phenylpyridinium (MPP+) leads to the degeneration of dopaminergic neurons in man and …

Parkinson's disease (PD) is a complex and multifaceted neurodegenerative disorder that
results from multiple environmental factors and multicellular interactions. Although several …

Multiple complex intracellular cascades contributing to Hunter syndrome (
mucopolysaccharidosis type II) pathogenesis have been recognized and documented in the …

Six new pentacyclic triterpenoid saponins, centelloside F (1), centelloside G (2), 11-oxo-
asiaticoside B (3), 11-oxo-madecassoside (4), 11 (β)-methoxy asiaticoside B (5), and 11 (β) …

Rotenone is one of the most widely used insecticide and pisicides in the US and around the
world. Epidemiological evidences suggest that rotenone exposure may be a risk factor for …

Gastrointestinal (GI) disturbances are one of the earliest symptoms affecting most patients
with Parkinson's disease (PD). In many cases, these symptoms are observed years before …

Background: Chronic environmental exposure to manganese (Mn) can cause debilitating
damage to the central nervous system. However, its potential toxic effects on the enteric …

One of the most significant risk variants for Parkinson's disease (PD), rs356182, is located at
the PD-associated locus near the alpha-synuclein (α-syn) encoding gene, SNCA. SNCA …