Reviewing the Clostridioides difficile Mouse Model: Insights into Infection Mechanisms

JL Fachi, MAR Vinolo, M Colonna - Microorganisms, 2024 - mdpi.com
Clostridioides difficile is an anaerobic, spore-forming bacterium associated with intestinal
infection, manifesting a broad spectrum of gastrointestinal symptoms, ranging from mild …

The state of play of rodent models for the study of Clostridioides difficile infection

A Brosse, H Coullon, C Janoir… - Journal of Medical …, 2024 - microbiologyresearch.org
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhoea and is responsible for a spectrum of diseases characterized by high levels of …

Evaluation of the therapeutic effect and dose–effect of Bifidobacterium breve on the primary Clostridioides difficile infected mice

J Yang, H Yang - Applied Microbiology and Biotechnology, 2021 - Springer
Probiotics are widely used as an adjuvant agent for the prevention of primary Clostridioides
difficile infection (pCDI) and are less commonly used in the treatment of pCDI. Here, the …

Therapeutic effects of Bifidobacterium breve YH68 in combination with Vancomycin and metronidazole in a primary clostridioides difficile-infected mouse model

J Yang, L Meng, H Yang - Microbiology Spectrum, 2022 - Am Soc Microbiol
Probiotics have been widely used to prevent primary Clostridioides difficile infection (pCDI);
however, there are fewer studies on their therapeutic aspects for pCDI. In this study, high …

Strong Antimicrobial Effects of Xanthohumol and Beta-Acids from Hops against Clostridioides difficile Infection In Vivo

R Sleha, V Radochova, A Mikyska, M Houska… - Antibiotics, 2021 - mdpi.com
Clostridioides (C.) difficile is an important causative pathogen of nosocomial gastrointestinal
infections in humans with an increasing incidence, morbidity, and mortality. The available …

Metabolic Phenotyping Study of Mouse Brain Following Microbiome Disruption by C. difficile Colonization

O Deda, M Kachrimanidou, EG Armitage… - Metabolites, 2022 - mdpi.com
Clostridioides difficile infection (CDI) is responsible for an increasing number of cases of
post-antibiotic diarrhea worldwide, which has high severity and mortality among hospitalized …

Specific adsorption of a β-lactam antibiotic in vivo by an anion-exchange resin for protection of the intestinal microbiota

S Li, K Yakabe, K Zai, Y Liu, A Kishimura, K Hase… - Biomaterials …, 2021 - pubs.rsc.org
The fraction of antibiotics that are excreted from the intestine during administration leads to
disruption of commensal bacteria as well as resulting in dysbiosis and various diseases. To …

Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model

ND Budi, JJ Godfrey, N Safdar… - The Journal of …, 2023 - academic.oup.com
Background Clostridioides difficile infections (CDI) and recurrence (rCDI) are major health
care burdens. Recurrence is likely caused by spores in the gastrointestinal tract that …

Outbreaks of Typhlocolitis caused by hypervirulent group ST1 Clostridioides difficile in highly immunocompromised strains of mice

KGL Ma, K Lertpiriyapong, A Piersigilli… - Comparative …, 2020 - ingentaconnect.com
Clostridioides difficile is an enteric pathogen that can cause significant clinical disease in
both humans and animals. However, clinical disease arises most commonly after treatment …

[HTML][HTML] CHAPSAP26-161, A Truncated Protein and Enzymatic Active Domain of Endolysin LysSAP26, as a Potential Therapeutic Agent to Combat Clostridioides …

RH Dahal, YJ Choi, S Kim… - Journal of Bacteriology …, 2024 - synapse.koreamed.org
Clostridioides difficile is a spore-forming enteric pathogen that causes life-threatening
diarrhea and colitis. Notably, C. difficile infection (CDI) is a major healthcare-associated …