Postoperative cognitive dysfunction (POCD) is a prevalent clinical entity following surgery
and is characterized by declined neurocognitive function. Neuroinflammation mediated by …

Central nervous system injuries are a leading cause of death and disability worldwide.
Although the exact pathophysiological mechanisms of various brain injuries vary, central …

Background. Exposure of infant animals to clinically used anaesthetics is associated with
acute structural brain abnormalities and development functional alterations. The α2 …

General anaesthesia may impose significant neurocognitive risks on the developing brain.
As brain injury in preterm neonates has a particular predilection for cerebral white matter, we …

Ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68) is a member of
proton-sensing G-protein-coupled receptors, involved in cardiovascular physiology, tumor …

The use of general anesthetics in modern clinical practice is commonly regarded as safe for
healthy individuals, but exposures at the extreme ends of the age spectrum have been …

Background Long-term effects of early, recurrent human exposure to general anaesthesia
remain unknown. The Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) trial …

Studies on fluorinated inhalation anesthetics, including synthesis, physical chemistry and
pharmacology, have been summarized in this review. Retrospecting the history of inhalation …

Numerous studies have demonstrated that general anesthetics might damage the nervous
system, thus, the effect of general anesthetics on the developing brain has attracted much …

Objectives The objective of this study was to evaluate whether melatonin could ameliorate
cognitive function in Aβ1-42-induced mouse model and its underlying mechanisms …