Comparative genetics of longevity and cancer: insights from long-lived rodents
Mammals have evolved a remarkable diversity of ageing rates. Within the single order of
Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats …
Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats …
Learning of nature: The curious case of the naked mole rat
FA Lagunas-Rangel, V Chávez-Valencia - Mechanisms of Ageing and …, 2017 - Elsevier
Naked mole rats (NMRs) are the longest-living rodents known, living up to approximately 30
years and showing sustained good health. Nowadays, NMRs are considered excellent …
years and showing sustained good health. Nowadays, NMRs are considered excellent …
Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes
X Fang, I Seim, Z Huang, MV Gerashchenko, Z Xiong… - Cell reports, 2014 - cell.com
Subterranean mammals spend their lives in dark, unventilated environments that are rich in
carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived …
carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived …
Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage
The naked mole-rat (Heterocephalus glaber) is a subterranean eusocial rodent with a
markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation …
markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation …
Why does insect RNA look degraded?
EC Winnebeck, CD Millar… - Journal of Insect …, 2010 - academic.oup.com
The integrity of extracted ribonucleic acid (RNA) is commonly assessed by gel
electrophoresis and subsequent analysis of the ribosomal RNA (rRNA) bands. Using the …
electrophoresis and subsequent analysis of the ribosomal RNA (rRNA) bands. Using the …
Translation fidelity coevolves with longevity
Whether errors in protein synthesis play a role in aging has been a subject of intense
debate. It has been suggested that rare mistakes in protein synthesis in young organisms …
debate. It has been suggested that rare mistakes in protein synthesis in young organisms …
Computational discovery of hidden breaks in 28S ribosomal RNAs across eukaryotes and consequences for RNA Integrity Numbers
In some eukaryotes, a 'hidden break'has been described in which the 28S ribosomal RNA
molecule is cleaved into two subparts. The break is common in protostome animals …
molecule is cleaved into two subparts. The break is common in protostome animals …
A DEAD box protein is required for formation of a hidden break in Arabidopsis chloroplast 23S rRNA
K Nishimura, H Ashida, T Ogawa, A Yokota - The Plant Journal, 2010 - Wiley Online Library
In plant chloroplasts, the ribosomal RNA (rRNA) of the large subunit of the ribosome
undergoes post‐maturation fragmentation processing. This processing consists of site …
undergoes post‐maturation fragmentation processing. This processing consists of site …
Revelations about aging and disease from unconventional vertebrate model organisms
Aging is a major risk factor for multiple diseases. Understanding the underlying mechanisms
of aging would help to delay and prevent age-associated diseases. Short-lived model …
of aging would help to delay and prevent age-associated diseases. Short-lived model …
The use of non-traditional models in the study of cancer resistance—the case of the naked mole rat
A Shepard, JL Kissil - Oncogene, 2020 - nature.com
Non-traditional model organisms are typically defined as any model the deviates from the
typical laboratory animals, such as mouse, rat, and worm. These models are becoming …
typical laboratory animals, such as mouse, rat, and worm. These models are becoming …