Biology presents many wonders, but one of the most remarkable is how a complex
multicellular organism grows from a single cell. Until recently, the processes involved …

With the advent of artemisinin resistance, it is timely to revisit the biological basis for the
controversial suggestion that this class of antimalarial exerts its activity by inhibiting a …

Plasmodium, Toxoplasma, Cryptosporidium, Babesia, and Theileria are the major
apicomplexan parasites affecting humans or animals worldwide. These pathogens …

The asexual blood stages of Plasmodium falciparum cause the most lethal form of human
malaria. During growth within an infected red blood cell, parasite multiplication and …

IP 3-dependent Ca 2+ signaling controls a myriad of cellular processes in higher eukaryotes
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …

More than 40% of the World population is at risk of contracting malaria, which affects
primarily poor populations in tropical and subtropical areas. Antimalarial pharmacotherapy …

Indole compounds are involved in a range of functions in many organisms. In the human
malaria parasite Plasmodium falciparum, melatonin and other tryptophan derivatives are …

TSSA (trypomastigote small surface antigen) is a polymorphic mucin-like molecule
displayed on the surface of Trypanosoma cruzi trypomastigote forms. To evaluate its …

Background Plasmodium has a complex biology including the ability to interact with host
signals modulating their function through cellular machinery. Tumor necrosis factor (TNF) …

We previously reported that melatonin modulates the Plasmodium falciparum erythrocytic
cycle by increasing schizont stage population as well as diminishing ring stage population …