An introduction to NMR-based approaches for measuring protein dynamics
IR Kleckner, MP Foster - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2011 - Elsevier
Proteins are inherently flexible at ambient temperature. At equilibrium, they are
characterized by a set of conformations that undergo continuous exchange within a …
characterized by a set of conformations that undergo continuous exchange within a …
Principles governing the phase separation of multidomain proteins
A variety of membraneless organelles, often termed “biological condensates”, play an
important role in the regulation of cellular processes such as gene transcription, translation …
important role in the regulation of cellular processes such as gene transcription, translation …
Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules …
Understanding the function of biological macromolecules and their complexes at the
physicochemical level requires knowledge of both their structure and dynamics …
physicochemical level requires knowledge of both their structure and dynamics …
Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
SAXS ensemble refinement of ESCRT-III CHMP3 conformational transitions
We developed and implemented an ensemble-refinement method to study dynamic
biomolecular assemblies with intrinsically disordered segments. Data from small angle X-ray …
biomolecular assemblies with intrinsically disordered segments. Data from small angle X-ray …
Efficient determination of protein–protein standard binding free energies from first principles
Characterizing protein–protein association quantitatively has been a long standing
challenge for computer simulations. Here, a theoretical framework is put forth that addresses …
challenge for computer simulations. Here, a theoretical framework is put forth that addresses …
Coarse-grained molecular simulations of large biomolecules
S Takada - Current opinion in structural biology, 2012 - Elsevier
Recently, we saw a dramatic increase in the number of researches that rely on coarse-
grained (CG) simulations for large biomolecules. Here, first, we briefly describe recently …
grained (CG) simulations for large biomolecules. Here, first, we briefly describe recently …
Molecular recognition and ligand association
R Baron, JA McCammon - Annual review of physical chemistry, 2013 - annualreviews.org
We review recent developments in our understanding of molecular recognition and ligand
association, focusing on two major viewpoints:(a) studies that highlight new physical insight …
association, focusing on two major viewpoints:(a) studies that highlight new physical insight …
Crystal structure and allosteric activation of protein kinase C βII
Protein kinase C (PKC) isozymes are the paradigmatic effectors of lipid signaling. PKCs
translocate to cell membranes and are allosterically activated upon binding of the lipid …
translocate to cell membranes and are allosterically activated upon binding of the lipid …
[HTML][HTML] The courtship of proteins: understanding the encounter complex
M Ubbink - FEBS letters, 2009 - Elsevier
The formation of protein complexes involves an encounter complex, in which proteins show
few specific interactions and assume many orientations. Recent kinetic and structural …
few specific interactions and assume many orientations. Recent kinetic and structural …