This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Angiogenesis is the growth of blood vessels from the existing vasculature. The field of
angiogenesis has grown enormously in the past 30 years, with only 40 papers published in …

Abstract Purpose of Review The main goal of this article is to discuss the role of the
epithelial sodium channel (ENaC) in extracellular fluid and blood pressure regulation …

The glycocalyx generally covers almost all cellular surfaces, where it participates in
mediating cell-surface interactions with the extracellular matrix as well as with intracellular …

Salt-sensitive hypertension is a major risk factor for cardiovascular morbidity and mortality.
The pathophysiologic mechanisms leading to different individual BP responses to changes …

A potential “new player” in arteries for mediating shear stress responses is the epithelial Na+
channel (ENaC). The contribution of ENaC as shear sensor in intact arteries, and particularly …

The pulmonary circulation is a low resistance and low pressure system. Sustained
pulmonary vasoconstriction and excessive vascular remodeling often occur under …

Tubuloglomerular feedback and the myogenic mechanism form an ensemble in renal
afferent arterioles that regulate single-nephron blood flow and glomerular filtration. Each …