Integrins dynamically equilibrate between three conformational states on cell surfaces. A
bent conformation has a closed headpiece. Two extended conformations contain either a …

The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

Chimeric antigen receptor (CAR) therapy has had a transformative effect on the treatment of
haematologic malignancies,,,,–, but it has shown limited efficacy against solid tumours. Solid …

CD8+ T cells within the tumor microenvironment (TME) are exposed to various signals that
ultimately determine functional outcomes. Here, we examined the role of the co-activating …

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized
variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional …

Recent advances in the understanding of T cell activation have led to new therapeutic
approaches in the treatment of immunological disorders. One attractive target of intervention …

Most patients with cancer do not develop durable antitumor responses after programmed
cell death protein 1 (PD-1) or programmed cell death ligand 1 (PD-L1) checkpoint inhibition …

T cell activation and function require a structured engagement of antigen-presenting cells.
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …

T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and
higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) …

Since the discovery that integrins at the surface of lymphocytes undergo dynamic changes in
their adhesive activity after stimulation through the T-cell receptor or stimulation with …