B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Human leucocyte antigen B* 27 (HLA-B* 27) is strongly associated with inflammatory
diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that …

B‐cell receptors and T‐cell receptors are the key molecules responsible for specific antigen
recognition in adaptive immunity. The huge diversity of immune receptor repertoires …

Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted
at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy …

Motivation High-throughput sequencing of large immune repertoires has enabled the
development of methods to predict the probability of generation by V (D) J recombination of …

Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a
vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant …

Objective Genetic studies on ankylosing spondylitis (AS) have identified more than 100
pathogenic genes. Building a bridge between these genes and biologically targeted …

Objective Ankylosing spondylitis (AS) is a common spondyloarthropathy primarily affecting
the axial skeleton and strongly associated with HLA–B* 27 carriage. Genetic evidence …

Spondyloarthritis (SpA) is a chronic inflammatory disease that is tightly linked to HLA-B* 27
but the pathophysiological basis of this link is still unknown. It is discussed whether either …

The last two decades have seen major developments in the field of spondyloarthritis (SpA),
but there are still important unmet needs to address. In the future, we envisage important …