G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter
systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

Promoting neurogenesis is a promising strategy for the treatment of cognition impairment
associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal …

Abstract β-arrestins are associated with numerous aspects of G protein–coupled receptor
(GPCR) signaling and regulation and accordingly influence diverse physiological and …

The G protein coupled receptors (GPCRs) have been considered as one of the largest
families of validated drug targets, which involve in almost overall physiological functions and …

Dementia conditions and memory deficits of different origins (vascular, metabolic and
primary neurodegenerative such as Alzheimer's and Parkinson's diseases) are getting more …

γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved
in many physiological processes. Their clinical relevance comes from their involvement in …

Alzheimer's disease (AD), the most common neurodegenerative disease, is characterized by
progressive cognitive impairment. The deposition of amyloid beta (Aβ) and …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the AβPP/PS1
transgenic mouse model is a commonly used experimental model to mimic the pathological …

Highlights•GPCRs are implicated in the pathophysiology of various neurodegenerative
diseases.•Currently available therapies do not cure the discussed neurodegenerative …