The role of G protein-coupled receptors in the pathology of Alzheimer's disease
A Thathiah, B De Strooper - Nature Reviews Neuroscience, 2011 - nature.com
G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter
systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly …
systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly …
An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases
BC Heng, D Aubel, M Fussenegger - Biotechnology advances, 2013 - Elsevier
G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …
neurotransmitters and hormones within the human body. They exhibit much structural and …
Polysaccharides from Ganoderma lucidum promote cognitive function and neural progenitor proliferation in mouse model of Alzheimer's disease
S Huang, J Mao, K Ding, Y Zhou, X Zeng, W Yang… - Stem cell reports, 2017 - cell.com
Promoting neurogenesis is a promising strategy for the treatment of cognition impairment
associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal …
associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal …
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
A Thathiah, K Horré, A Snellinx, E Vandewyer… - Nature medicine, 2013 - nature.com
Abstract β-arrestins are associated with numerous aspects of G protein–coupled receptor
(GPCR) signaling and regulation and accordingly influence diverse physiological and …
(GPCR) signaling and regulation and accordingly influence diverse physiological and …
G protein-coupled receptors (GPCRs) in Alzheimer's disease: a focus on BACE1 related GPCRs
J Zhao, Y Deng, Z Jiang, H Qing - Frontiers in aging neuroscience, 2016 - frontiersin.org
The G protein coupled receptors (GPCRs) have been considered as one of the largest
families of validated drug targets, which involve in almost overall physiological functions and …
families of validated drug targets, which involve in almost overall physiological functions and …
Neuropeptides in learning and memory
É Borbély, B Scheich, Z Helyes - Neuropeptides, 2013 - Elsevier
Dementia conditions and memory deficits of different origins (vascular, metabolic and
primary neurodegenerative such as Alzheimer's and Parkinson's diseases) are getting more …
primary neurodegenerative such as Alzheimer's and Parkinson's diseases) are getting more …
Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond
B De Strooper… - Annual review of …, 2015 - annualreviews.org
γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved
in many physiological processes. Their clinical relevance comes from their involvement in …
in many physiological processes. Their clinical relevance comes from their involvement in …
Understanding the modulatory effects of cannabidiol on Alzheimer's disease
Y Xiong, CS Lim - Brain Sciences, 2021 - mdpi.com
Alzheimer's disease (AD), the most common neurodegenerative disease, is characterized by
progressive cognitive impairment. The deposition of amyloid beta (Aβ) and …
progressive cognitive impairment. The deposition of amyloid beta (Aβ) and …
Novel object recognition as a facile behavior test for evaluating drug effects in AβPP/PS1 Alzheimer's disease mouse model
R Zhang, G Xue, S Wang, L Zhang… - Journal of Alzheimer's …, 2012 - content.iospress.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the AβPP/PS1
transgenic mouse model is a commonly used experimental model to mimic the pathological …
transgenic mouse model is a commonly used experimental model to mimic the pathological …
The role of GPCRs in neurodegenerative diseases: avenues for therapeutic intervention
Y Huang, N Todd, A Thathiah - Current opinion in pharmacology, 2017 - Elsevier
Highlights•GPCRs are implicated in the pathophysiology of various neurodegenerative
diseases.•Currently available therapies do not cure the discussed neurodegenerative …
diseases.•Currently available therapies do not cure the discussed neurodegenerative …