This review is a survey of various approaches to targeting cytotoxic anticancer drugs to
tumors primarily through biomolecules expressed by cancer cells or associated vasculature …

Oxidative stress has been causally linked to various diseases. Electron transport chain
(ETC) inhibitors such as rotenone and antimycin A are frequently used in model systems to …

Background Esterase enzymes differ in substrate specificity and biological function and may
display dysregulated expression in cancer. This study evaluated the biological significance …

Indenoisoquinoline topoisomerase I (Top1) inhibitors are a novel class of anticancer agents
with two compounds in clinical trials. Recent metabolism studies of indotecan (LMP400) led …

A major limitation of immune checkpoint inhibitors is that only a small subset of patients
achieve durable clinical responses. This necessitates the development of combinatorial …

Background Esterases are often overexpressed in cancer cells and can have chiral
specificities different from that of the corresponding normal tissues. For this reason, ester …

Introduction Immune checkpoint inhibitors that boost cytotoxic T cell-based immune
responses have emerged as one of the most promising approaches in cancer treatment …

A series of dichloro (ethylenediamine)-type platinum complexes bearing ester-, amide-and
ether-bonded alkyl straight chains (C2–C18) was prepared as a model for the prodrug of cis …

(±)-Ethyl 2-fluoro-2-phenylacetate was stereoselectively hydrolyzed by cultured cells of
several rat cancer cell lines to give the carboxylic acid rich in the R enantiomer. The …

Stereoselectivity in the hydrolysis of racemic ethyl 2‐phenylacetate derivatives by cultured
cells of noncancerous cell lines from rat liver (BRL, BRL 3A, Clone 9, and ARLJ301–3) …