Cell polarity is defined as asymmetry in cell shape, protein distributions and cell functions. It
is characteristic of single-cell organisms, including yeast and bacteria, and cells in tissues of …

The intestine is one of the major organs in C. elegans and is largely responsible for food
digestion and assimilation as well as the synthesis and storage of macromolecules. In …

▪ Abstract The polarized architecture of epithelial cells and tissues is a fundamental
determinant of animal anatomy and physiology. Recent progress made in the genetic and …

Polarized cells contain numerous membrane domains, but it is unclear how the formation of
these domains is coordinated to create a single integrated cell architecture. Genetic screens …

Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on
the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites …

The neoplastic tumour suppressors, Scribble, Dlg and Lgl, originally discovered in the
vinegar fly Drosophila melanogaster, are currently being actively studied for their potential …

The polarized nature of epithelial cells is manifested by the nonrandom partitioning of
organelles within the cells, the concentration of intercellular junctions at one pole, and the …

Circletail is one of only two mouse mutants that exhibit the most severe form of neural tube
defect (NTD), termed craniorachischisis. In this disorder, almost the entire brain and spinal …

The function of epithelial cell sheets depends on the integrity of specialized cell–cell
junctions that connect neighbouring cells. We have characterized the novel coiled-coil …

Members of the LAP protein family, LET-413 in Caenorhabditis elegans, Scribble in
Drosophila melanogaster and Erbin, Lano, Densin-180 and hScrib in mammals, have …