The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP)
superfamily members are found in a remarkable range of organisms spanning each of the …

The scientific study of human hookworm infection began at the dawn of the twentieth
century. In recent years, there have been dramatic improvements in our understanding of …

Adolescence is a developmental period in which the mesolimbic dopaminergic “reward”
circuitry of the brain, including the nucleus accumbens (NAc), undergoes significant …

Integrin α M β 2 (Mac-1, CD11b/CD18) is a noncovalently linked heterodimer of α M and β 2
subunits on the surface of leukocytes, where it plays a pivotal role in the adhesion and …

ICAMs are ligands for LFA-1, a major integrin of mononuclear cells involved in the immune
and inflammatory processes. We previously showed that endothelial cell specific molecule-1 …

Leukocyte trafficking into pulmonary tissue and airspaces is a critical component of the host
defense response. Activation and migration of polymorphonuclear leukocytes (PMNs) into …

The β2-integrin receptor family has a broad spectrum of physiological functions ranging from
leukocyte adhesion, cell migration, activation, and communication to the phagocytic uptake …

The frequent inflammatory responses to implanted medical devices are puzzling in view of
the inert and nontoxic nature of most biomaterials. Because implant surfaces spontaneously …

Hookworms infect perhaps one-fifth of the entire human population, yet little is known about
their interaction with our immune system. The two major species are Necator americanus …

Leukocyte-derived microparticles (MPs) are markers of cardiovascular diseases and
contribute to pathogenesis by their interaction with various cell types. The presence and …