Control of blood flow distribution and tissue homeostasis depend on the tight regulation of
and coordination between the microvascular network and circulating blood cells. Channels …

Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming
proteins that are critically involved in many aspects of vascular physiology and pathology …

Rationale: Resistant hypertension is a major health concern with unknown cause.
Spironolactone is an effective antihypertensive drug, especially for patients with resistant …

Pannexin 1 (PANX1)-mediated ATP release in vascular smooth muscle coordinates α1-
adrenergic receptor (α1-AR) vasoconstriction and blood pressure homeostasis. We recently …

Objective—Sympathetic nerve innervation of vascular smooth muscle cells (VSMCs) is a
major regulator of arteriolar vasoconstriction, vascular resistance, and blood pressure …

Coordination of vascular smooth muscle cell tone in resistance arteries plays an essential
role in the regulation of peripheral resistance and overall blood pressure. Recent …

Background Trovafloxacin is a broad-spectrum antibiotic, recently identified as an inhibitor of
pannexin-1 (Panx1) channels. Panx1 channels are important conduits for the adenosine …

Many β-adrenoceptor agonists and antagonists including several clinically used drugs have
been reported to also exhibit binding to α 1-adrenoceptors. Such promiscuity within the …

Microcirculation homeostasis depends on several channels permeable to ions and/or small
molecules that facilitate the regulation of the vasomotor tone, hyperpermeability, the blood …

New drugs introduced in the market each year, have privileged structures specifically for
anticancer targets, of which quinoline-based analogues also play an important role. This …