An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …

Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous
system (CNS), is the major cause of cognitive and motor dysfunction. While neuronal …

The mammalian CNS contains a ubiquitous population of glial progenitors known as NG2+
cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in …

Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and
receptors involved in genomic and non-genomic effects. In addition to classical bone-related …

Although often considered as a group, spinal motor neurons are highly diverse in terms of
their morphology, connectivity, and functional properties and differ significantly in their …

Microglia cells are the major orchestrator of the brain inflammatory response. As such, they
are traditionally studied in various contexts of trauma, injury, and disease, where they are …

Amyotrophic lateral sclerosis (ALS) is a severe progressive neurodegenerative disease. The
cause is unknown, but genetic abnormalities have been identified in subjects with familial …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterised by the degeneration of upper and lower motor neurons. Recent advances in …

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that
causes selective death of motor neurons followed by paralysis and death. A subset of ALS …

The motor neuron (MN) degenerative disease, spinal muscular atrophy (SMA) is caused by
deficiency of SMN (survival motor neuron), a ubiquitous and indispensable protein essential …