[HTML][HTML] Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases
Z Liu, Y Sun, Z Qi, L Cao, S Ding - Cell & bioscience, 2022 - Springer
Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …
These organelles are highly dynamic, constantly changing their morphology, cellular …
[HTML][HTML] New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …
[HTML][HTML] An epigenetic role of mitochondria in cancer
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism
Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …
[HTML][HTML] Mitochondria targeting as an effective strategy for cancer therapy
Mitochondria are well known for their role in ATP production and biosynthesis of
macromolecules. Importantly, increasing experimental evidence points to the roles of …
macromolecules. Importantly, increasing experimental evidence points to the roles of …
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state
Eradicating triple-negative breast cancer (TNBC) resistant to neoadjuvant chemotherapy
(NACT) is a critical unmet clinical need. In this study, patient-derived xenograft (PDX) …
(NACT) is a critical unmet clinical need. In this study, patient-derived xenograft (PDX) …
[HTML][HTML] Stem cell plasticity and dormancy in the development of cancer therapy resistance
ML De Angelis, F Francescangeli, F La Torre… - Frontiers in …, 2019 - frontiersin.org
Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …
[HTML][HTML] Metabolic plasticity in chemotherapy resistance
MA Desbats, I Giacomini, T Prayer-Galetti… - Frontiers in …, 2020 - frontiersin.org
Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …
Thus, new strategies to deal with the evasion of drug response and to improve clinical …
Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma
Background & Aims Little is known about the metabolic regulation of cancer stem cells
(CSCs) in cholangiocarcinoma (CCA). We analyzed whether mitochondrial-dependent …
(CSCs) in cholangiocarcinoma (CCA). We analyzed whether mitochondrial-dependent …
[HTML][HTML] How and why are cancers acidic? Carbonic anhydrase IX and the homeostatic control of tumour extracellular pH
SH Lee, JR Griffiths - Cancers, 2020 - mdpi.com
The acidic tumour microenvironment is now recognized as a tumour phenotype that drives
cancer somatic evolution and disease progression, causing cancer cells to become more …
cancer somatic evolution and disease progression, causing cancer cells to become more …