The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design

E Gallo - Journal of Biomedical Science, 2024 - Springer
Synthetic antibodies (Abs) represent a category of artificial proteins capable of closely
emulating the functions of natural Abs. Their in vitro production eliminates the need for an …

Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples

M Forinová, A Pilipenco, I Visova… - … applied materials & …, 2021 - ACS Publications
New analytical techniques that overcome major drawbacks of current routinely used viral
infection diagnosis methods, ie, the long analysis time and laboriousness of real-time …

Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV‐1

PD Kwong, GY Chuang, BJ DeKosky… - Immunological …, 2017 - Wiley Online Library
Numerous antibodies have been identified from HIV‐1‐infected donors that neutralize
diverse strains of HIV‐1. These antibodies may provide the basis for a B cell‐mediated HIV …

Development of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT)

CY Wu, JJ Lin, WY Chang, CY Hsieh, CC Wu… - Colloids and Surfaces B …, 2019 - Elsevier
Successful boron neutron capture therapy (BNCT) requires sufficient and specific delivery of
boron atoms to malignant cells. Gold nanoparticles (AuNPs) have been used as a useful …

A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells

YA Ko, YH Yu, YF Wu, YC Tseng, CL Chen… - PloS …, 2021 - journals.plos.org
Hemagglutinin (HA) is the immunodominant protein of the influenza virus. We previously
showed that mice injected with a monoglycosylated influenza A HA (HAmg) produced cross …

The interfacial character of antibody paratopes: analysis of antibody–antigen structures

MN Nguyen, MR Pradhan, C Verma, P Zhong - Bioinformatics, 2017 - academic.oup.com
In this study, computational methods are applied to investigate the general properties of
antigen engaging residues of a paratope from a non-redundant dataset of 403 antibody …

Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic …

HJ Hsu, CP Tung, CM Yu, CY Chen, HS Chen… - Scientific Reports, 2021 - nature.com
Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and
hence there are increasing needs to develop MSLN-targeting strategies for cancer …

Preparation and characterization of antibody-drug conjugates acting on HER2-positive cancer cells

ZC Chiang, YK Chiu, CC Lee, NS Hsu, YL Tsou… - PLoS …, 2020 - journals.plos.org
Two systems of antibody-drug conjugates (ADCs), noncleavable H32-DM1 and cleavable
H32-VCMMAE, were developed by using different linkers and drugs attached to the anti …

Structure-based development of human interleukin-1β-specific antibody that simultaneously inhibits binding to both IL-1RI and IL-1RAcP

WC Kuo, CC Lee, YW Chang, W Pang, HS Chen… - Journal of Molecular …, 2021 - Elsevier
Abstract Interleukin-1β (IL-1β) is a potent pleiotropic cytokine playing a central role in
protecting cells from microbial pathogen infection or endogenous stress. After it binds to IL …

Noninvasive assessment of characteristics of novel anti-HER2 antibodies by molecular imaging in a human gastric cancer xenograft-bearing mouse model

WY Kuo, JJ Lin, HJ Hsu, HS Chen, AS Yang, CY Wu - Scientific reports, 2018 - nature.com
Human epidermal growth factor receptor 2 (HER2) overexpression occurs in various types of
cancers. Regarding the anti-HER2 targeted therapies showed superior treatment outcomes …