The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design
E Gallo - Journal of Biomedical Science, 2024 - Springer
Synthetic antibodies (Abs) represent a category of artificial proteins capable of closely
emulating the functions of natural Abs. Their in vitro production eliminates the need for an …
emulating the functions of natural Abs. Their in vitro production eliminates the need for an …
Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples
M Forinová, A Pilipenco, I Visova… - … applied materials & …, 2021 - ACS Publications
New analytical techniques that overcome major drawbacks of current routinely used viral
infection diagnosis methods, ie, the long analysis time and laboriousness of real-time …
infection diagnosis methods, ie, the long analysis time and laboriousness of real-time …
Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV‐1
PD Kwong, GY Chuang, BJ DeKosky… - Immunological …, 2017 - Wiley Online Library
Numerous antibodies have been identified from HIV‐1‐infected donors that neutralize
diverse strains of HIV‐1. These antibodies may provide the basis for a B cell‐mediated HIV …
diverse strains of HIV‐1. These antibodies may provide the basis for a B cell‐mediated HIV …
Development of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT)
Successful boron neutron capture therapy (BNCT) requires sufficient and specific delivery of
boron atoms to malignant cells. Gold nanoparticles (AuNPs) have been used as a useful …
boron atoms to malignant cells. Gold nanoparticles (AuNPs) have been used as a useful …
A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells
YA Ko, YH Yu, YF Wu, YC Tseng, CL Chen… - PloS …, 2021 - journals.plos.org
Hemagglutinin (HA) is the immunodominant protein of the influenza virus. We previously
showed that mice injected with a monoglycosylated influenza A HA (HAmg) produced cross …
showed that mice injected with a monoglycosylated influenza A HA (HAmg) produced cross …
The interfacial character of antibody paratopes: analysis of antibody–antigen structures
In this study, computational methods are applied to investigate the general properties of
antigen engaging residues of a paratope from a non-redundant dataset of 403 antibody …
antigen engaging residues of a paratope from a non-redundant dataset of 403 antibody …
Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic …
Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and
hence there are increasing needs to develop MSLN-targeting strategies for cancer …
hence there are increasing needs to develop MSLN-targeting strategies for cancer …
Preparation and characterization of antibody-drug conjugates acting on HER2-positive cancer cells
ZC Chiang, YK Chiu, CC Lee, NS Hsu, YL Tsou… - PLoS …, 2020 - journals.plos.org
Two systems of antibody-drug conjugates (ADCs), noncleavable H32-DM1 and cleavable
H32-VCMMAE, were developed by using different linkers and drugs attached to the anti …
H32-VCMMAE, were developed by using different linkers and drugs attached to the anti …
Structure-based development of human interleukin-1β-specific antibody that simultaneously inhibits binding to both IL-1RI and IL-1RAcP
WC Kuo, CC Lee, YW Chang, W Pang, HS Chen… - Journal of Molecular …, 2021 - Elsevier
Abstract Interleukin-1β (IL-1β) is a potent pleiotropic cytokine playing a central role in
protecting cells from microbial pathogen infection or endogenous stress. After it binds to IL …
protecting cells from microbial pathogen infection or endogenous stress. After it binds to IL …
Noninvasive assessment of characteristics of novel anti-HER2 antibodies by molecular imaging in a human gastric cancer xenograft-bearing mouse model
Human epidermal growth factor receptor 2 (HER2) overexpression occurs in various types of
cancers. Regarding the anti-HER2 targeted therapies showed superior treatment outcomes …
cancers. Regarding the anti-HER2 targeted therapies showed superior treatment outcomes …