Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis
are underlying causal components of diet-induced obesity in rodent models. This review …

Obesity and its comorbidities are long-standing, challenging global health problems. Lack of
exercise, overnutrition, and especially the consumption of fat-rich foods are some of the most …

Modern food environments are conducive to overeating and weight gain, but not everyone
develops obesity. One reason for this may be that individuals differ in appetitive …

OBJECTIVE Preclinical research implicates hypothalamic glial cell responses in the
pathogenesis of obesity and type 2 diabetes (T2D). In the current study we sought to …

Neuroinflammation is both a consequence and driver of overfeeding and weight gain in
rodent obesity models. Advances in magnetic resonance imaging (MRI) enable …

In experimental models, hypothalamic dysfunction is a key component of the
pathophysiology of diet-induced obesity. Early after the introduction of a high-fat diet …

Chronic low-grade inflammation is a feature of the pathophysiology of obesity and diabetes
in the CNS as well as peripheral tissues. Glial cells are critical mediators of the response to …

Intrauterine exposure to metabolic dysfunction leads to offspring metabolic dysfunction in
human and rodent models, but underlying mechanisms are unclear. The mediobasal …

Astrocytes are no longer considered as passive support cells. In the hypothalamus, these
glial cells actively participate in the control of appetite, energy expenditure, and the …

Objective This study investigated, in a large pediatric population, whether magnetic
resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis is associated …