Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …

Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …

Epigenetic approaches for estimating the age of living organisms are revolutionizing studies
of long‐lived species. Molecular biomarkers that allow age estimates from small tissue …

Age‐associated DNA‐methylation profiles have been used successfully to develop highly
accurate biomarkers of age (" epigenetic clocks") in humans, mice, dogs, and other species …

Age determination of wild animals, including pinnipeds, is critical for accurate population
assessment and management. For most pinnipeds, current age estimation methodologies …

The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory
care and experimental manipulation, and unique biology, is the most used laboratory …