Towards an understanding of psychedelic-induced neuroplasticity

AE Calder, G Hasler - Neuropsychopharmacology, 2023 - nature.com
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

[HTML][HTML] Psychedelics and neuroplasticity: a systematic review unraveling the biological underpinnings of psychedelics

CMH De Vos, NL Mason, KPC Kuypers - Frontiers in psychiatry, 2021 - frontiersin.org
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

MK Doss, M Považan, MD Rosenberg… - Translational …, 2021 - nature.com
Psilocybin has shown promise for the treatment of mood disorders, which are often
accompanied by cognitive dysfunction including cognitive rigidity. Recent studies have …

Treatment of posttraumatic stress disorder: a state-of-the-art review

L Burback, S Brult-Phillips, MJ Nijdam… - Current …, 2024 - benthamdirect.com
This narrative state-of-the-art review paper describes the progress in the understanding and
treatment of Posttraumatic Stress Disorder (PTSD). Over the last four decades, the scientific …

Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics

LR Aleksandrova, AG Phillips - Trends in pharmacological sciences, 2021 - cell.com
The emerging therapeutic efficacy of ketamine and classical psychedelics for depression
has inspired tremendous interest in the underlying neurobiological mechanisms. We review …

Default mode network modulation by psychedelics: a systematic review

JJ Gattuso, D Perkins, S Ruffell… - International Journal …, 2023 - academic.oup.com
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well
as profound psychological and mystical experiences. A grouping of interconnected brain …

A non-hallucinogenic LSD analog with therapeutic potential for mood disorders

V Lewis, EM Bonniwell, JK Lanham, A Ghaffari… - Cell reports, 2023 - cell.com
Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting
antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) …

Hallucinogens in mental health: preclinical and clinical studies on LSD, psilocybin, MDMA, and ketamine

D De Gregorio, A Aguilar-Valles, KH Preller… - Journal of …, 2021 - Soc Neuroscience
A revamped interest in the study of hallucinogens has recently emerged, especially with
regard to their potential application in the treatment of psychiatric disorders. In the last …

Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics

AM Jaster, J González-Maeso - Molecular psychiatry, 2023 - nature.com
Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants

W Duan, D Cao, S Wang, J Cheng - Chemical Reviews, 2023 - ACS Publications
Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …