[HTML][HTML] Call to action to properly utilize electron microscopy to measure organelles to monitor disease

K Neikirk, EG Lopez, AG Marshall, A Alghanem… - European Journal of …, 2023 - Elsevier
This review provides an overview of the current methods for quantifying mitochondrial
ultrastructure, including cristae morphology, mitochondrial contact sites, and recycling …

Mitochondria in disease: changes in shapes and dynamics

BC Jenkins, K Neikirk, P Katti, SM Claypool… - Trends in biochemical …, 2024 - cell.com
Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …

Mitochondrial structure and function in human heart failure

A Hinton Jr, SM Claypool, K Neikirk, N Senoo… - Circulation …, 2024 - ahajournals.org
Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments

AO Hinton Jr, AU N'jai, Z Vue, C Wanjalla - Circulation Research, 2024 - Am Heart Assoc
HIV infection and antiretroviral therapy alter mitochondrial function, which can progressively
lead to mitochondrial damage and accelerated aging. The interaction between persistent …

ATF4‐dependent increase in mitochondrial‐endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle

A Hinton Jr, P Katti, M Mungai, DD Hall… - Journal of Cellular …, 2024 - Wiley Online Library
Mitochondria and endoplasmic reticulum (ER) contact sites (MERCs) are protein‐and lipid‐
enriched hubs that mediate interorganellar communication by contributing to the dynamic …

Considerations for developing mitochondrial transplantation techniques for individualized medicine

K Neikirk, DC Stephens, HK Beasley, AG Marshall… - …, 2024 - Taylor & Francis
Tweetable abstract Mitochondrial transplantation has been used to treat various diseases
associated with mitochondrial dysfunction. Here, we highlight the considerations in quality …

Running a successful STEMM summer program: A week‐by‐week guide

HK Beasley, Z Vue, MR McReynolds… - Journal of Cellular …, 2024 - Wiley Online Library
While some established undergraduate summer programs are effective across many
institutions, these programs may only be available to some principal investigators or may not …

A Workshop to Enrich Physiological Understanding Through Hands-On Learning About Mitochondria-Endoplasmic Reticulum Contact Sites

Z Vue, C Vang, CN Wanjalla… - Advances in …, 2024 - journals.physiology.org
Physiology is an important field for students to gain a better understanding of biological
mechanisms. Yet, many students often find it difficult to learn from lectures, resulting in poor …

Quantitative assessment of morphological changes in lipid droplets and lipid–mito interactions with aging in brown adipose

A Crabtree, K Neikirk, JA Pinette… - Journal of Cellular …, 2023 - Wiley Online Library
The physical characteristics of brown adipose tissue (BAT) are defined by the presence of
multilocular lipid droplets (LDs) within the brown adipocytes and a high abundance of iron …

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

B Shao, M Killion, A Oliver, C Vang… - Journal of Cellular …, 2024 - Wiley Online Library
The sorting and assembly machinery (SAM) Complex is responsible for assembling β‐barrel
proteins in the mitochondrial membrane. Comprising three subunits, Sam35, Sam37, and …