Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

The etiology of the common, sporadic form of Alzheimer's disease (sAD) is unknown. We
hypothesize that tau pathology within select projection neurons with susceptible …

The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …

Brain derived neurotrophic factor (BDNF) has multiple biological functions which are
mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor …

Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

The present study was designed to investigate the role of β‐amyloid (Aβ1‐42) in inducing
neuronal pyroptosis and its mechanism. Mice cortical neurons (MCNs) were used in this …

Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical
value in Asian countries, have a long usage history in China for the therapy of some …

A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …

Introduction Alzheimer's disease (AD) is a devastating condition with no effective treatments,
with promising findings in rodents failing to translate into successful therapies for patients …

As the average age of the population continues to rise, the number of individuals affected
with age-related cognitive decline and Alzheimer's disease (AD) has increased and is …